GPS-Lipid - Prediction of Lipid Modifications (S-Palmitoylation, N-Myristoylation, S-Farnesylation, S-Geranylgeranylation)


※ Prediction of lipid modification sites

If your sequences > 1000, please download the local version to predict. The local version is more powerful and has more functions.

     Enter sequence(s) in FASTA format

PTM Type
Palmitoylation N-Myristoylation Farnesylation Geranylgeranylation
Console
 
Threshold
High              Medium              Low              All


 All the spaces, line breaks  will be automatically removed. You could input one primary sequence or multiple proteins'  sequences in FASTA format.

After lipid modification predictor model was well-trained, we performed an evaluation on this model. From the evaluation, three thresholds with High, Medium and Low stringency were chosen for lipid modification. The performance under these three thresholds was presented as follow:

The performance of lipid modifications in different threshold
Modification Type
Threshold
Ac
Sn
Sp
MCC
Pr
S-Palmitoylation
High
0.9305
0.8365
0.9487
0.7556
0.7594
Medium
0.8939
0.864
0.8997
0.6751
0.6252
Low
0.8624
0.9208
0.8511
0.6379
0.5448
N-Myristoylation
High
0.9908
0.8584
0.9953
0.8537
0.8584
Medium
0.9799
0.9204
0.9819
0.7525
0.6303
Low
0.9519
0.9646
0.9514
0.6038
0.3993
S-Farnesylation
High
0.9324
0.8171
0.9478
0.706
0.6768
Medium
0.9309
0.8902
0.9364
0.7253
0.6518
Low
0.9252
0.9634
0.9201
0.7353
0.6172
S-Geranylgeranylation
High
0.9696
0.9437
0.9792
0.9228
0.9437
Medium
0.9429
0.9577
0.9375
0.8638
0.8500
Low
0.9202
0.9859
0.8958
0.8251
0.7778