LipidDB ID

LipidDB-99287-00663

Entry Name

UniProt Accession

Q56061;

Theoretical PI

5.91

Molecular Weight

38498.4

Genbank Protein ID

AAA97467.1; AAL20153.1;

Genbank Nucleotide ID

U51867; AE006468;

Protein Name

Secreted effector protein SifA

Protein Synonyms/Alias

Gene Name

sifA

Gene Synonyms/Alias

STM1224;

Created Date

01-NOV-1997

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

NCBI Taxa ID

99287

Reference

[1] Reinicke AT, Hutchinson JL, Magee AI, Mastroeni P, Trowsdale J, Kelly AP. ASalmonella typhimurium effector protein SifA is modified by host cell prenylationand S-acylation machinery. J Biol Chem. 2005 Apr 15;280(15):14620-7. Epub 2005Feb 14.[PMID:15710609]
[2] Hicks SW, Galán JE. Exploitation of eukaryotic subcellular targetingmechanisms by bacterial effectors. Nat Rev Microbiol. 2013 May;11(5):316-26. doi:10.1038/nrmicro3009. Review.[PMID:23588250]

Functional Description

Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella- induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.

Sequence Annotation

Region: 1 330 Interaction with host PLEKHM2.

Protein Length

336 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0009405; P:pathogenesis; IEA:UniProtKB-KW

Interpro

InterPro; IPR010637; Sif

Pfam

Pfam; PF06767; Sif;

SMART

PROSITE

PRINTS