Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9913-01407
Entry Name
UniProt Accession
Theoretical PI
4.39
Molecular Weight
31664.77
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Myristoylated alanine-rich C-kinase substrate
Protein Synonyms/Alias
MARCKS; ACAMP-81;
Gene Name
MARCKS
Gene Synonyms/Alias
MACS;
Created Date
01-OCT-1989
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGAQFSKTA
[1]
N-Myristoylation
Organism
Bos taurus (Bovine)
NCBI Taxa ID
9913
Reference
[1] Taniguchi H, Manenti S, Suzuki M, Titani K. Myristoylated alanine-rich Ckinase substrate (MARCKS), a major protein kinase C substrate, is an in vivosubstrate of proline-directed protein kinase(s). A mass spectroscopic analysis ofthe post-translational modifications. J Biol Chem. 1994 Jul 15;269(28):18299-302.[PMID:8034575]
Functional Description
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Sequence Annotation
Region: 151 175 Calmodulin-binding (PSD).
Modified residue: 27 27 Phosphoserine.
Modified residue: 46 46 Phosphoserine.
Modified residue: 63 63 Phosphoserine.
Modified residue: 77 77 Phosphoserine.
Modified residue: 81 81 Phosphoserine.
Modified residue: 100 100 Phosphoserine.
Modified residue: 117 117 Phosphoserine; by MAPK.
Modified residue: 134 134 Phosphoserine.
Modified residue: 142 142 Phosphothreonine.
Modified residue: 144 144 Phosphoserine.
Modified residue: 149 149 Phosphothreonine.
Modified residue: 158 158 Phosphoserine; by PKC.
Modified residue: 162 162 Phosphoserine; by PKC.
Modified residue: 166 166 Phosphoserine; by PKC.
Modified residue: 169 169 Phosphoserine; by PKC.
Modified residue: 264 264 Phosphoserine.
Protein Length
333 AA.
Protein Sequence
(Canonical)
MGAQFSKTAA KGEATAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA EPGAKEELQA  60
NGSAPAADKE EPAAAGSGAA SPAAAEKDEP AAAAPDAGAS PVEKEAPVEG EAAEPGSPTA  120
AEGEAASAAS STSSPKAEDG ATPSPSNETP KKKKKRFSFK KSFKLSGFSF KKNKKEAGEG  180
GEAEGAAGAS AEGGKDEASG GAAAAAGEAG AAPGEPTAAP GEEAAAGEEG AAGGDPQEAK  240
PEEAAVAPEK PPASEEAKAV EEPSKAEEKA EEAGVSAAGC EAPSAAGPGV PPEQEAAPAE  300
EAAAAPASSA CAAPSQEAQP ECSPEAPPAE AAE                               333
FASTA
(Canonical)
>LipidDB-9913-01407|P12624
MGAQFSKTAAKGEATAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAEPGAKEELQA
NGSAPAADKEEPAAAGSGAASPAAAEKDEPAAAAPDAGASPVEKEAPVEGEAAEPGSPTA
AEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEG
GEAEGAAGASAEGGKDEASGGAAAAAGEAGAAPGEPTAAPGEEAAAGEEGAAGGDPQEAK
PEEAAVAPEKPPASEEAKAVEEPSKAEEKAEEAGVSAAGCEAPSAAGPGVPPEQEAAPAE
EAAAAPASSACAAPSQEAQPECSPEAPPAEAAE
Gene Ontology
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
Interpro
InterPro; IPR002101; MARCKS
Pfam
Pfam; PF02063; MARCKS;
SMART
PROSITE
PROSITE; PS00826; MARCKS_1;
PROSITE; PS00827; MARCKS_2;
PRINTS
PRINTS; PR00963; MARCKS;