Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9913-01069
Entry Name
UniProt Accession
Theoretical PI
4.7
Molecular Weight
25066.07
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Neuromodulin
Protein Synonyms/Alias
Axonal membrane protein GAP-43; Calmodulin-binding protein P-57; Growth-associated protein 43;
Gene Name
GAP43
Gene Synonyms/Alias
Created Date
01-JAN-1988
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
3
Canonical
*****MLCCMRRTKQ
[1]
S-Palmitoylation
4
Canonical
****MLCCMRRTKQV
[1]
S-Palmitoylation
Organism
Bos taurus (Bovine)
NCBI Taxa ID
9913
Reference
[1] Liu Y, Fisher DA, Storm DR. Analysis of the palmitoylation and membranetargeting domain of neuromodulin (GAP-43) by site-specific mutagenesis.Biochemistry. 1993 Oct 12;32(40):10714-9.[PMID:8399217]
Functional Description
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
Sequence Annotation
Domain: 31 60 IQ.
Region: 1 4 Important for membrane binding.
Modified residue: 41 41 Phosphoserine; by PHK and PKC.
Modified residue: 206 206 Phosphoserine; by CK2.
Modified residue: 207 207 Phosphoserine; by CK2.
Protein Length
242 AA.
Protein Sequence
(Canonical)
MLCCMRRTKQ VEKNDEDQKI EQDGIKPEDK AHKAATKIQA SFRGHITRKK LKGEKKGDAP  60
AAEAEANEKD EAAVAEGTEK KEGEGSTPAE AAPGAGPKPE EKTGKAGETP SEEKKGEGAP  120
DAATEQAAPQ APAPSEEKAG SAETESATKA STDNSPSSKA EDAPAKEEPK QADVPAAVTA  180
AAATAPAAED AAAMATAQPP TETAESSQAE EKIEAVDETK PKDSARQDEG KGEEREADQE  240
HA                                                                 242
FASTA
(Canonical)
>LipidDB-9913-01069|P06836
MLCCMRRTKQVEKNDEDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKGDAP
AAEAEANEKDEAAVAEGTEKKEGEGSTPAEAAPGAGPKPEEKTGKAGETPSEEKKGEGAP
DAATEQAAPQAPAPSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA
AAATAPAAEDAAAMATAQPPTETAESSQAEEKIEAVDETKPKDSARQDEGKGEEREADQE
HA
Gene Ontology
GO:0030424; C:axon; IEA:Ensembl
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0031527; C:filopodium membrane; IEA:Ensembl
GO:0045202; C:synapse; IEA:UniProtKB-KW
GO:0016198; P:axon choice point recognition; IEA:Ensembl
GO:0045165; P:cell fate commitment; IEA:Ensembl
GO:0010001; P:glial cell differentiation; IEA:Ensembl
GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl
GO:0040008; P:regulation of growth; IEA:UniProtKB-KW
Interpro
InterPro; IPR000048; IQ_motif_EF-hand-BS
InterPro; IPR001422; Neuromodulin
InterPro; IPR017454; Neuromodulin_C
InterPro; IPR018947; Neuromodulin_gap-junction_N
InterPro; IPR018243; Neuromodulin_palmitoyl/P_site
Pfam
Pfam; PF00612; IQ;
Pfam; PF06614; Neuromodulin;
Pfam; PF10580; Neuromodulin_N;
SMART
SMART; SM00015; IQ;
PROSITE
PROSITE; PS50096; IQ;
PROSITE; PS00412; NEUROMODULIN_1;
PROSITE; PS00413; NEUROMODULIN_2;
PRINTS
PRINTS; PR00215; NEUROMODULIN;