LipidDB ID

LipidDB-9913-01063

Entry Name

UniProt Accession

P04896; Q0II85; Q3SZE7;

Theoretical PI

5.5

Molecular Weight

45708.59

Genbank Protein ID

CAA27137.1; AAA30560.1; AAI02906.1; AAI22758.1; AAA30557.1;

Genbank Nucleotide ID

X03404; M13006; BC102905; BC122757; M14014;

Protein Name

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Protein Synonyms/Alias

Adenylate cyclase-stimulating G alpha protein;

Gene Name

GNAS

Gene Synonyms/Alias

GNAS1;

Created Date

13-AUG-1987

Organism

Bos taurus (Bovine)

NCBI Taxa ID

9913

Reference

[1] Kleuss C, Krause E. Galpha(s) is palmitoylated at the N-terminal glycine. EMBOJ. 2003 Feb 17;22(4):826-32.[PMID:12574119]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Stimulates the Ras signaling pathway via RAPGEF2 (By similarity).

Sequence Annotation

Nucleotide-binding: 47 54 GTP.
Nucleotide-binding: 198 204 GTP.
Nucleotide-binding: 223 227 GTP.
Nucleotide-binding: 292 295 GTP.
Metal binding site: 54 54 Magnesium.
Metal binding site: 204 204 Magnesium.
Binding site: 366 366 GTP; via amide nitrogen.
Modified residue: 352 352 Phosphoserine.

Protein Length

394 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030425; C:dendrite; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IEA:InterPro
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0004871; F:signal transducer activity; ISS:UniProtKB
GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; ISS:UniProtKB
GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IEA:Ensembl
GO:0051216; P:cartilage development; IEA:Ensembl
GO:0050890; P:cognition; IEA:Ensembl
GO:0048589; P:developmental growth; IEA:Ensembl
GO:0006306; P:DNA methylation; IEA:Ensembl
GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl
GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl
GO:0001958; P:endochondral ossification; IEA:Ensembl
GO:0006112; P:energy reserve metabolic process; IEA:Ensembl
GO:0071514; P:genetic imprinting; IEA:Ensembl
GO:0060789; P:hair follicle placode formation; IEA:Ensembl
GO:0035264; P:multicellular organism growth; IEA:Ensembl
GO:0070527; P:platelet aggregation; IEA:Ensembl
GO:0030819; P:positive regulation of cAMP biosynthetic process; ISS:UniProtKB
GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB
GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl
GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl
GO:0032320; P:positive regulation of Ras GTPase activity; ISS:UniProtKB
GO:0040032; P:post-embryonic body morphogenesis; IEA:Ensembl
GO:0042493; P:response to drug; IEA:Ensembl
GO:0001894; P:tissue homeostasis; IEA:Ensembl

Interpro

InterPro; IPR000367; Gprotein_alpha_S
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase

Pfam

Pfam; PF00503; G-alpha;

SMART

SMART; SM00275; G_alpha;

PROSITE

PRINTS

PRINTS; PR00318; GPROTEINA;
PRINTS; PR00443; GPROTEINAS;