Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9913-01042
Entry Name
UniProt Accession
Theoretical PI
4.4
Molecular Weight
23510.36
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Guanylyl cyclase-activating protein 1
Protein Synonyms/Alias
GCAP 1; Guanylate cyclase activator 1A;
Gene Name
GUCA1A
Gene Synonyms/Alias
GCAP1; GUCA1;
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGNIMDGKS
[1]
N-Myristoylation
Organism
Bos taurus (Bovine)
NCBI Taxa ID
9913
Reference
[1] Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, HuangJ, Zhao X, Crabb JW, Johnson RS, et al. Molecular cloning and characterization ofretinal photoreceptor guanylyl cyclase-activating protein. Neuron. 1994Aug;13(2):395-404.[PMID:7520254]
Functional Description
Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Sequence Annotation
Domain: 14 49 EF-hand 1.
Domain: 51 86 EF-hand 2.
Domain: 87 122 EF-hand 3.
Domain: 131 166 EF-hand 4.
Modified residue: 3 3 Deamidated asparagine.
Protein Length
205 AA.
Protein Sequence
(Canonical)
MGNIMDGKSV EELSSTECHQ WYKKFMTECP SGQLTLYEFR QFFGLKNLSP WASQYVEQMF  60
ETFDFNKDGY IDFMEYVAAL SLVLKGKVEQ KLRWYFKLYD VDGNGCIDRD ELLTIIRAIR  120
AINPCSDSTM TAEEFTDTVF SKIDVNGDGE LSLEEFMEGV QKDQMLLDTL TRSLDLTRIV  180
RRLQNGEQDE EGASGRETEA AEADG                                        205
FASTA
(Canonical)
>LipidDB-9913-01042|P46065
MGNIMDGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPWASQYVEQMF
ETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIRAIR
AINPCSDSTMTAEEFTDTVFSKIDVNGDGELSLEEFMEGVQKDQMLLDTLTRSLDLTRIV
RRLQNGEQDEEGASGRETEAAEADG
Gene Ontology
GO:0005886; C:plasma membrane; IEA:Ensembl
GO:0005509; F:calcium ion binding; IEA:InterPro
GO:0008048; F:calcium sensitive guanylate cyclase activator activity; ISS:AgBase
GO:0030249; F:guanylate cyclase regulator activity; ISS:AgBase
GO:0007602; P:phototransduction; ISS:AgBase
GO:0031284; P:positive regulation of guanylate cyclase activity; ISS:GOC
GO:0031282; P:regulation of guanylate cyclase activity; ISS:AgBase
GO:0007601; P:visual perception; ISS:AgBase
Interpro
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
InterPro; IPR028846; Recoverin
Pfam
Pfam; PF00036; EF-hand_1;
Pfam; PF13202; EF-hand_5;
SMART
SMART; SM00054; EFh;
PROSITE
PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;
PRINTS