LipidDB ID

LipidDB-9913-01016

Entry Name

UniProt Accession

P02698;

Theoretical PI

4.76

Molecular Weight

8543.9

Genbank Protein ID

AAA30794.1; AAA30793.1; AAB26895.1; AAB26895.1; AAA30788.1;

Genbank Nucleotide ID

K03255; K02199; S62031; S62029; K02436;

Protein Name

Guanine nucleotide-binding protein G(T) subunit gamma-T1

Protein Synonyms/Alias

Transducin gamma chain;

Gene Name

GNGT1

Gene Synonyms/Alias

Created Date

21-JUL-1986

Organism

Bos taurus (Bovine)

NCBI Taxa ID

9913

Reference

[1] Sanford J, Codina J, Birnbaumer L. Gamma-subunits of G proteins, but not theiralpha- or beta-subunits, are polyisoprenylated. Studies on post-translationalmodifications using in vitro translation with rabbit reticulocyte lysates. J BiolChem. 1991 May 25;266(15):9570-9.[PMID:1903391]
[2] Fukada Y, Takao T, Ohguro H, Yoshizawa T, Akino T, Shimonishi Y. Farnesylated gamma-subunit of photoreceptor G protein indispensable for GTP-binding. Nature.1990 Aug 16;346(6285):658-60.[PMID:2385292]
[3] Lai RK, Perez-Sala D, Cañada FJ, Rando RR. The gamma subunit of transducin is farnesylated. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7673-7.[PMID:2217200]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Sequence Annotation

Modified residue: 71 71 Cysteine methyl ester.

Protein Length

74 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro
GO:0097381; C:photoreceptor disc membrane; TAS:Reactome
GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW
GO:0042462; P:eye photoreceptor cell development; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro
GO:0007602; P:phototransduction; IEA:Ensembl
GO:0008104; P:protein localization; IEA:Ensembl

Interpro

InterPro; IPR015898; G-protein_gamma-like_dom
InterPro; IPR001770; Gprotein-gamma

Pfam

Pfam; PF00631; G-gamma;

SMART

SMART; SM00224; GGL;

PROSITE

PROSITE; PS50058; G_PROTEIN_GAMMA;

PRINTS

PRINTS; PR00321; GPROTEING;