Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9913-00955
Entry Name
UniProt Accession
Theoretical PI
7.62
Molecular Weight
20440.03
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Pulmonary surfactant-associated protein C
Protein Synonyms/Alias
SP-C; Pulmonary surfactant-associated proteolipid SPL(Val);
Gene Name
SFTPC
Gene Synonyms/Alias
SFTP2;
Created Date
01-APR-1990
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
28
Canonical
GGRLLIPCCPVNIKR
[1]
S-Palmitoylation
29
Canonical
GRLLIPCCPVNIKRL
[1]
S-Palmitoylation
Organism
Bos taurus (Bovine)
NCBI Taxa ID
9913
Reference
[1] Stults JT, Griffin PR, Lesikar DD, Naidu A, Moffat B, Benson BJ. Lungsurfactant protein SP-C from human, bovine, and canine sources contains palmityl cysteine thioester linkages. Am J Physiol. 1991 Aug;261(2 Pt 1):L118-25. Erratum in: Am J Physiol 1992 Mar;262(3 Pt 1):L242. Am J Physiol 1992 Jun;262(6 Pt3):section L followi.[PMID:1872406]
Functional Description
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces.
Sequence Annotation
Domain: 94 190 BRICHOS.
Protein Length
190 AA.
Protein Sequence
(Canonical)
MDVGSKEVLM ESPPDYTAVP GGRLLIPCCP VNIKRLLIVV VVVVLVVVVI VGALLMGLHM  60
SQKHTEMVLE MSITGPEAQQ RLALSERVGT TATFSIGSTG TVVYDYQRLL IAYKPAPGTC  120
CYIMKMAPQN IPSLEALTRK LQNFQAKPQV PSSKLGQEQG HDAGSAFSGD LAFLGRTVST  180
LCGEVPLYYT                                                         190
FASTA
(Canonical)
>LipidDB-9913-00955|P15783
MDVGSKEVLMESPPDYTAVPGGRLLIPCCPVNIKRLLIVVVVVVLVVVVIVGALLMGLHM
SQKHTEMVLEMSITGPEAQQRLALSERVGTTATFSIGSTGTVVYDYQRLLIAYKPAPGTC
CYIMKMAPQNIPSLEALTRKLQNFQAKPQVPSSKLGQEQGHDAGSAFSGDLAFLGRTVST
LCGEVPLYYT
Gene Ontology
GO:0005737; C:cytoplasm; IEA:Ensembl
GO:0005576; C:extracellular region; IEA:UniProtKB-KW
GO:0007585; P:respiratory gaseous exchange; IEA:UniProtKB-KW
Interpro
InterPro; IPR007084; BRICHOS_dom
InterPro; IPR018051; SP-C_palmitoylation_site
InterPro; IPR015091; Surfactant_protein_propep
Pfam
Pfam; PF04089; BRICHOS;
Pfam; PF08999; SP_C-Propep;
SMART
SMART; SM01039; BRICHOS;
PROSITE
PROSITE; PS50869; BRICHOS;
PROSITE; PS00341; SURFACT_PALMITOYL;
PRINTS