LipidDB ID

LipidDB-9913-00755

Entry Name

UniProt Accession

P63212; P16874; Q2KI31; Q61013; Q9TS47;

Theoretical PI

7.78

Molecular Weight

7850.14

Genbank Protein ID

AAA30541.1; AAA30555.1; AAI12790.1;

Genbank Nucleotide ID

J05071; M37183; BC112789;

Protein Name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Protein Synonyms/Alias

G gamma-I;

Gene Name

GNG2

Gene Synonyms/Alias

Created Date

27-SEP-2004

Organism

Bos taurus (Bovine)

NCBI Taxa ID

9913

Reference

[1] Sanford J, Codina J, Birnbaumer L. Gamma-subunits of G proteins, but not theiralpha- or beta-subunits, are polyisoprenylated. Studies on post-translationalmodifications using in vitro translation with rabbit reticulocyte lysates. J BiolChem. 1991 May 25;266(15):9570-9.[PMID:1903391]
[2] Wilcox MD, Schey KL, Busman M, Hildebrandt JD. Determination of the completecovalent structure of the gamma 2 subunit of bovine brain G proteins by massspectrometry. Biochem Biophys Res Commun. 1995 Jul 17;212(2):367-74.[PMID:7626050]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Sequence Annotation

Modified residue: 2 2 N-acetylalanine.
Modified residue: 68 68 Cysteine methyl ester.

Protein Length

71 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005834; C:heterotrimeric G-protein complex; IDA:BHF-UCL
GO:0016020; C:membrane; IDA:BHF-UCL
GO:0031681; F:G-protein beta-subunit binding; ISS:UniProt
GO:0003924; F:GTPase activity; IDA:MGI
GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW
GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:BHF-UCL
GO:0008283; P:cell proliferation; IEA:Ensembl
GO:0071870; P:cellular response to catecholamine stimulus; IDA:BHF-UCL
GO:0071380; P:cellular response to prostaglandin E stimulus; IDA:BHF-UCL
GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI
GO:0006184; P:GTP catabolic process; IDA:GOC

Interpro

InterPro; IPR015898; G-protein_gamma-like_dom
InterPro; IPR001770; Gprotein-gamma

Pfam

Pfam; PF00631; G-gamma;

SMART

SMART; SM00224; GGL;

PROSITE

PROSITE; PS50058; G_PROTEIN_GAMMA;

PRINTS

PRINTS; PR00321; GPROTEING;