Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9913-00742
Entry Name
UniProt Accession
Theoretical PI
6.8
Molecular Weight
34121.67
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
NADH-cytochrome b5 reductase 3 soluble form
Protein Synonyms/Alias
B5R; Cytochrome b5 reductase; 1.6.2.2; Diaphorase-1;
Gene Name
CYB5R3
Gene Synonyms/Alias
DIA1;
Created Date
01-APR-1988
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGAQLSTLG
[1]
N-Myristoylation
Organism
Bos taurus (Bovine)
NCBI Taxa ID
9913
Reference
[1] Ozols J, Carr SA, Strittmatter P. Identification of the NH2-terminal blocking group of NADH-cytochrome b5 reductase as myristic acid and the complete aminoacid sequence of the membrane-binding domain. J Biol Chem. 1984 Nov10;259(21):13349-54.[PMID:6436247]
Functional Description
Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Sequence Annotation
Domain: 40 152 FAD-binding FR-type.
Nucleotide-binding: 132 147 FAD.
Nucleotide-binding: 171 206 FAD.
Modified residue: 42 42 N6-acetyllysine.
Modified residue: 43 43 Phosphotyrosine.
Modified residue: 50 50 N6-acetyllysine.
Modified residue: 120 120 N6-acetyllysine.
Protein Length
301 AA.
Protein Sequence
(Canonical)
MGAQLSTLGH VVLSPVWFLY SLIMKLFQRS TPAITLENPD IKYPLRLIDK EVISHDTRRF  60
RFALPSPEHI LGLPVGQHIY LSARIDGNLV IRPYTPVSSD DDKGFVDLVI KVYFKDTHPK  120
FPAGGKMSQY LESMKIGDTI EFRGPNGLLV YQGKGKFAIR PDKKSDPVIK TVKSVGMIAG  180
GTGITPMLQV IRAIMKDPDD HTVCHLLFAN QTEKDILLRP ELEELRNEHS ARFKLWYTVD  240
KAPEAWDYSQ GFVNEEMIRD HLPPPEEEPL VLMCGPPPMI QYACLPNLDR VGHPKERCFA  300
F                                                                  301
FASTA
(Canonical)
>LipidDB-9913-00742|P07514
MGAQLSTLGHVVLSPVWFLYSLIMKLFQRSTPAITLENPDIKYPLRLIDKEVISHDTRRF
RFALPSPEHILGLPVGQHIYLSARIDGNLVIRPYTPVSSDDDKGFVDLVIKVYFKDTHPK
FPAGGKMSQYLESMKIGDTIEFRGPNGLLVYQGKGKFAIRPDKKSDPVIKTVKSVGMIAG
GTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNEHSARFKLWYTVD
KAPEAWDYSQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDRVGHPKERCFA
F
Gene Ontology
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-KW
GO:0004128; F:cytochrome-b5 reductase activity, acting on NAD(P)H; IEA:UniProtKB-EC
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW
Interpro
InterPro; IPR017927; Fd_Rdtase_FAD-bd
InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase
InterPro; IPR001834; NADH-Cyt_B5_reductase
InterPro; IPR008333; OxRdtase_FAD-bd_dom
InterPro; IPR001433; OxRdtase_FAD/NAD-bd
InterPro; IPR017938; Riboflavin_synthase-like_b-brl
Pfam
Pfam; PF00970; FAD_binding_6;
Pfam; PF00175; NAD_binding_1;
SMART
PROSITE
PROSITE; PS51384; FAD_FR;
PRINTS
PRINTS; PR00406; CYTB5RDTASE;
PRINTS; PR00371; FPNCR;