LipidDB ID

LipidDB-9913-00657

Entry Name

UniProt Accession

P21457;

Theoretical PI

5.32

Molecular Weight

23333.42

Genbank Protein ID

AAB59256.1; CAA44928.1;

Genbank Nucleotide ID

M95858; X63322;

Protein Name

Recoverin

Protein Synonyms/Alias

p26;

Gene Name

RCVRN

Gene Synonyms/Alias

RCV1;

Created Date

01-MAY-1991

Organism

Bos taurus (Bovine)

NCBI Taxa ID

9913

Reference

[1] Dizhoor AM, Ericsson LH, Johnson RS, Kumar S, Olshevskaya E, Zozulya S,Neubert TA, Stryer L, Hurley JB, Walsh KA. The NH2 terminus of retinal recoverin is acylated by a small family of fatty acids. J Biol Chem. 1992 Aug15;267(23):16033-6.[PMID:1386601]
[2] Dizhoor AM, Chen CK, Olshevskaya E, Sinelnikova VV, Phillipov P, Hurley JB.Role of the acylated amino terminus of recoverin in Ca(2+)-dependent membraneinteraction. Science. 1993 Feb 5;259(5096):829-32.[PMID:8430337]

Functional Description

Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.

Sequence Annotation

Domain: 24 59 EF-hand 1.
Domain: 61 96 EF-hand 2.
Domain: 97 132 EF-hand 3.
Domain: 147 182 EF-hand 4.

Protein Length

202 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005829; C:cytosol; TAS:Reactome
GO:0005509; F:calcium ion binding; IEA:Ensembl
GO:0007602; P:phototransduction; IEA:Ensembl
GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl
GO:0007601; P:visual perception; IEA:UniProtKB-KW

Interpro

InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
InterPro; IPR028846; Recoverin

Pfam

Pfam; PF00036; EF-hand_1;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;

PRINTS