LipidDB ID

LipidDB-9913-00613

Entry Name

UniProt Accession

P28088; Q0VCB3; Q9TSB9;

Theoretical PI

9.02

Molecular Weight

49371.37

Genbank Protein ID

BAA01762.1; BAA14422.1; AAI20257.1;

Genbank Nucleotide ID

D10994; D90456; BC120256;

Protein Name

Endothelin B receptor

Protein Synonyms/Alias

ET-B; ET-BR; Endothelin receptor non-selective type;

Gene Name

EDNRB

Gene Synonyms/Alias

Created Date

01-AUG-1992

Organism

Bos taurus (Bovine)

NCBI Taxa ID

9913

Reference

[1] Roos M, Soskic V, Poznanovic S, Godovac-Zimmermann J. Post-translationalmodifications of endothelin receptor B from bovine lungs analyzed by massspectrometry. J Biol Chem. 1998 Jan 9;273(2):924-31.[PMID:9422751]

Functional Description

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Sequence Annotation

Topological domain: 27 100 Extracellular.
Transmembrane: 101 125 Helical; Name=1.
Topological domain: 126 136 Cytoplasmic.
Transmembrane: 137 162 Helical; Name=2.
Topological domain: 163 174 Extracellular.
Transmembrane: 175 196 Helical; Name=3.
Topological domain: 197 217 Cytoplasmic.
Transmembrane: 218 242 Helical; Name=4.
Topological domain: 243 270 Extracellular.
Transmembrane: 271 295 Helical; Name=5.
Topological domain: 296 323 Cytoplasmic.
Transmembrane: 324 349 Helical; Name=6.
Topological domain: 350 361 Extracellular.
Transmembrane: 362 388 Helical; Name=7.
Topological domain: 389 441 Cytoplasmic.
Modified residue: 304 304 Phosphoserine.
Modified residue: 418 418 Phosphoserine.
Modified residue: 434 434 Phosphoserine.
Modified residue: 435 435 Phosphoserine.
Modified residue: 438 438 Phosphotyrosine.
Modified residue: 439 439 Phosphoserine.
Modified residue: 440 440 Phosphoserine.
Modified residue: 441 441 Phosphoserine.

Protein Length

441 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004962; F:endothelin receptor activity; IEA:Ensembl
GO:0017046; F:peptide hormone binding; IEA:Ensembl
GO:0048484; P:enteric nervous system development; IEA:Ensembl
GO:0035645; P:enteric smooth muscle cell differentiation; IEA:Ensembl
GO:0048246; P:macrophage chemotaxis; IEA:Ensembl
GO:0030318; P:melanocyte differentiation; IEA:Ensembl
GO:0032269; P:negative regulation of cellular protein metabolic process; IEA:Ensembl
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0001755; P:neural crest cell migration; IEA:Ensembl
GO:0007422; P:peripheral nervous system development; IEA:Ensembl
GO:0007497; P:posterior midgut development; IEA:Ensembl
GO:0008217; P:regulation of blood pressure; IEA:Ensembl
GO:0006885; P:regulation of pH; IEA:Ensembl
GO:0014826; P:vein smooth muscle contraction; IEA:Ensembl

Interpro

InterPro; IPR000499; Endthln_rcpt
InterPro; IPR001112; ETB_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00571; ENDOTHELINBR;
PRINTS; PR00366; ENDOTHELINR;
PRINTS; PR00237; GPCRRHODOPSN;