| Tag |
Content |
LipidDB ID |
LipidDB-9913-00611 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.34 |
Molecular Weight |
40066.57 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Guanine nucleotide-binding protein G(o) subunit alpha |
Protein Synonyms/Alias |
GTP-binding protein G39; |
Gene Name |
GNAO1 |
Gene Synonyms/Alias |
|
Created Date |
01-AUG-1988 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGCTLSAEE | [1] | N-Myristoylation |
|
Organism |
Bos taurus (Bovine) |
NCBI Taxa ID |
9913 |
Reference |
[1] Schultz AM, Tsai SC, Kung HF, Oroszlan S, Moss J, Vaughan M.Hydroxylamine-stable covalent linkage of myristic acid in G0 alpha, a guaninenucleotide-binding protein of bovine brain. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1234-9.[ PMID:3113429]
|
Functional Description |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity). |
Sequence Annotation |
Nucleotide-binding: 40 47 GTP.
Nucleotide-binding: 176 182 GTP.
Nucleotide-binding: 201 205 GTP.
Nucleotide-binding: 270 273 GTP.
Metal binding site: 47 47 Magnesium.
Metal binding site: 182 182 Magnesium.
Binding site: 326 326 GTP; via amide nitrogen.
|
Protein Length |
354 AA. |
Protein Sequence
(Canonical) |
MGCTLSAEER AALERSKAIE KNLKEDGISA AKDVKLLLLG AGESGKSTIV KQMKIIHEDG 60
FSGEDVKQYK PVVYSNTIQS LAAIVRAMDT LGIEYGDKER KADAKMVCDV VSRMEDTEPF 120
SPELLSAMMR LWGDSGIQEC FNRSREYQLN DSAKYYLDSL DRIGAADYQP TEQDILRTRV 180
KTTGIVETHF TFKNLHFRLF DVGGQRSERK KWIHCFEDVT AIIFCVALSG YDQVLHEDET 240
TNRMHESLML FDSICNNKFF IDTSIILFLN KKDLFGEKIK KSPLTICFPE YTGSNTYEDA 300
AAYIQAQFES KNRSPNKEIY CHMTCATDTN NIQVVFDAVT DIIIANNLRG CGLY 354
|
FASTA
(Canonical) |
>LipidDB-9913-00611|P08239
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDG
FSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPF
SPELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRV
KTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDET
TNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGSNTYEDA
AAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
|
Gene Ontology |
GO:0005622; C:intracellular; IEA:Ensembl GO:0005525; F:GTP binding; IEA:UniProtKB-KW GO:0003924; F:GTPase activity; IEA:InterPro GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IEA:InterPro GO:0007212; P:dopamine receptor signaling pathway; IEA:Ensembl GO:0007626; P:locomotory behavior; IEA:Ensembl GO:0008016; P:regulation of heart contraction; IEA:Ensembl |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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