LipidDB ID

LipidDB-9913-00555

Entry Name

UniProt Accession

Q2KJ93;

Theoretical PI

6.16

Molecular Weight

21258.61

Genbank Protein ID

AAI05462.1;

Genbank Nucleotide ID

AAFC03029033; AAFC03029034; AAFC03029036; AAFC03128156; BC105461;

Protein Name

Cell division control protein 42 homolog

Protein Synonyms/Alias

Gene Name

CDC42

Gene Synonyms/Alias

Created Date

09-JAN-2007

Organism

Bos taurus (Bovine)

NCBI Taxa ID

9913

Reference

[1] Yamane HK, Farnsworth CC, Xie HY, Evans T, Howald WN, Gelb MH, Glomset JA,Clarke S, Fung BK. Membrane-binding domain of the small G protein G25K containsan S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus.Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):286-90.[PMID:1898776]

Functional Description

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (By similarity).

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 115 118 GTP.
Motif: 32 40 Effector region.
Modified residue: 64 64 Phosphotyrosine; by SRC.
Modified residue: 188 188 Cysteine methyl ester.

Protein Length

191 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0016020; C:membrane; ISS:UniProtKB
GO:0030496; C:midbody; ISS:UniProtKB
GO:0072686; C:mitotic spindle; ISS:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0051233; C:spindle midzone; ISS:UniProtKB
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW
GO:0007399; P:nervous system development; IEA:UniProtKB-KW
GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB
GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; ISS:UniProtKB
GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; ISS:UniProtKB
GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00174; RHO;

PROSITE

PROSITE; PS51420; RHO;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;