LipidDB ID

LipidDB-9913-00481

Entry Name

UniProt Accession

P63099; P06705; P15117; Q08044;

Theoretical PI

4.64

Molecular Weight

19299.91

Genbank Protein ID

CAA50659.1;

Genbank Nucleotide ID

X71666;

Protein Name

Calcineurin subunit B type 1

Protein Synonyms/Alias

Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1;

Gene Name

PPP3R1

Gene Synonyms/Alias

CNA2; CNB;

Created Date

01-JAN-1988

Organism

Bos taurus (Bovine)

NCBI Taxa ID

9913

Reference

[1] Aitken A, Klee CB, Cohen P. The structure of the B subunit of calcineurin. EurJ Biochem. 1984 Mar 15;139(3):663-71.[PMID:6321184]

Functional Description

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Sequence Annotation

Domain: 18 51 EF-hand 1.
Domain: 50 85 EF-hand 2.
Domain: 87 122 EF-hand 3.
Domain: 128 163 EF-hand 4.
Modified residue: 106 106 Phosphotyrosine.

Protein Length

170 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005829; C:cytosol; TAS:Reactome
GO:0042383; C:sarcolemma; IEA:Ensembl
GO:0005509; F:calcium ion binding; IEA:InterPro
GO:0004721; F:phosphoprotein phosphatase activity; IEA:Ensembl
GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl
GO:0007507; P:heart development; IEA:Ensembl
GO:0060487; P:lung epithelial cell differentiation; IEA:Ensembl
GO:0051531; P:NFAT protein import into nucleus; IEA:Ensembl
GO:0001569; P:patterning of blood vessels; IEA:Ensembl
GO:0006470; P:protein dephosphorylation; IEA:Ensembl

Interpro

InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom

Pfam

Pfam; PF00036; EF-hand_1;
Pfam; PF13499; EF-hand_7;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;

PRINTS