LipidDB ID

LipidDB-9913-00236

Entry Name

UniProt Accession

P11023; Q17QM2;

Theoretical PI

4.85

Molecular Weight

24953.88

Genbank Protein ID

AAA30416.1; AAI18279.1;

Genbank Nucleotide ID

M19885; BC118278;

Protein Name

Ras-related protein Rab-3A

Protein Synonyms/Alias

SMG P25A;

Gene Name

RAB3A

Gene Synonyms/Alias

Created Date

01-JUL-1989

Organism

Bos taurus (Bovine)

NCBI Taxa ID

9913

Reference

[1] Farnsworth CC, Kawata M, Yoshida Y, Takai Y, Gelb MH, Glomset JA. C terminusof the small GTP-binding protein smg p25A contains two geranylgeranylatedcysteine residues and a methyl ester. Proc Natl Acad Sci U S A. 1991 Jul15;88(14):6196-200.[PMID:1906176]

Functional Description

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).

Sequence Annotation

Nucleotide-binding: 29 36 GTP.
Nucleotide-binding: 48 54 GTP.
Nucleotide-binding: 77 81 GTP.
Nucleotide-binding: 135 138 GTP.
Motif: 51 59 Effector region.
Modified residue: 220 220 Cysteine methyl ester.

Protein Length

220 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0001669; C:acrosomal vesicle; IEA:Ensembl
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0008021; C:synaptic vesicle; ISS:AgBase
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; ISS:AgBase
GO:0007409; P:axonogenesis; ISS:AgBase
GO:0030324; P:lung development; ISS:AgBase
GO:0048790; P:maintenance of presynaptic active zone structure; ISS:AgBase
GO:0007005; P:mitochondrion organization; ISS:AgBase
GO:0007274; P:neuromuscular synaptic transmission; ISS:AgBase
GO:0009791; P:post-embryonic development; ISS:AgBase
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0017157; P:regulation of exocytosis; ISS:AgBase
GO:0031630; P:regulation of synaptic vesicle fusion to presynaptic membrane; ISS:AgBase
GO:0003016; P:respiratory system process; ISS:AgBase
GO:0051602; P:response to electrical stimulus; ISS:AgBase
GO:0050975; P:sensory perception of touch; ISS:AgBase
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0016079; P:synaptic vesicle exocytosis; ISS:AgBase
GO:0016188; P:synaptic vesicle maturation; ISS:AgBase

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;