Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9913-00048
Entry Name
UniProt Accession
Theoretical PI
5.91
Molecular Weight
62933.99
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Rhodopsin kinase
Protein Synonyms/Alias
RK; 2.7.11.14; G protein-coupled receptor kinase 1;
Gene Name
GRK1
Gene Synonyms/Alias
RHOK;
Created Date
01-DEC-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
558
Canonical
PSSKSGMCVLS****
[1]
S-Farnesylation
Organism
Bos taurus (Bovine)
NCBI Taxa ID
9913
Reference
[1] Inglese J, Glickman JF, Lorenz W, Caron MG, Lefkowitz RJ. Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. J Biol Chem. 1992 Jan 25;267(3):1422-5.[PMID:1730692]
Functional Description
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity).
Sequence Annotation
Domain: 58 172 RGS.
Domain: 187 452 Protein kinase.
Domain: 453 518 AGC-kinase C-terminal.
Nucleotide-binding: 193 201 ATP.
Region: 1 186 N-terminal.
Region: 453 561 C-terminal.
Active site: 314 314 Proton acceptor.
Binding site: 216 216 ATP.
Modified residue: 5 5 Phosphoserine.
Modified residue: 8 8 Phosphothreonine.
Modified residue: 21 21 Phosphoserine; by PKA and autocatalysis.
Modified residue: 488 488 Phosphoserine; by autocatalysis.
Modified residue: 489 489 Phosphothreonine; by autocatalysis.
Modified residue: 558 558 Cysteine methyl ester.
Protein Length
561 AA.
Protein Sequence
(Canonical)
MDFGSLETVV ANSAFIAARG SFDASSGPAS RDRKYLARLK LPPLSKCEAL RESLDLGFEG  60
MCLEQPIGKR LFQQFLRTHE QHGPALQLWK DIEDYDTADD ALRPQKAQAL RAAYLEPQAQ  120
LFCSFLDAET VARARAGAGD GLFQPLLRAV LAHLGQAPFQ EFLDSLYFLR FLQWKWLEAQ  180
PMGEDWFLDF RVLGRGGFGE VFACQMKATG KLYACKKLNK KRLKKRKGYQ GAMVEKKILA  240
KVHSRFIVSL AYAFETKTDL CLVMTIMNGG DIRYHIYNVD EDNPGFQEPR AIFYTAQIVS  300
GLEHLHQRNI IYRDLKPENV LLDDDGNVRI SDLGLAVELK AGQTKTKGYA GTPGFMAPEL  360
LLGEEYDFSV DYFALGVTLY EMIAARGPFR ARGEKVENKE LKQRVLEQAV TYPDKFSPAS  420
KDFCEALLQK DPEKRLGFRD GSCDGLRTHP LFRDISWRQL EAGMLTPPFV PDSRTVYAKN  480
IQDVGAFSTV KGVAFEKADT EFFQEFASGT CPIPWQEEMI ETGVFGDLNV WRPDGQMPDD  540
MKGVSGQEAA PSSKSGMCVL S                                            561
FASTA
(Canonical)
>LipidDB-9913-00048|P28327
MDFGSLETVVANSAFIAARGSFDASSGPASRDRKYLARLKLPPLSKCEALRESLDLGFEG
MCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQ
LFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQ
PMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILA
KVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS
GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL
LLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPAS
KDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKN
IQDVGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDGQMPDD
MKGVSGQEAAPSSKSGMCVLS
Gene Ontology
GO:0097381; C:photoreceptor disc membrane; TAS:Reactome
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0004703; F:G-protein coupled receptor kinase activity; IEA:InterPro
GO:0050254; F:rhodopsin kinase activity; ISS:UniProtKB
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl
GO:0008594; P:photoreceptor cell morphogenesis; IEA:Ensembl
GO:0042327; P:positive regulation of phosphorylation; IEA:Ensembl
GO:0060060; P:post-embryonic retina morphogenesis in camera-type eye; IEA:Ensembl
GO:0046777; P:protein autophosphorylation; ISS:UniProtKB
GO:0022400; P:regulation of rhodopsin mediated signaling pathway; ISS:UniProtKB
GO:0009416; P:response to light stimulus; IEA:Ensembl
GO:0007165; P:signal transduction; IEA:InterPro
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro
GO:0007601; P:visual perception; IEA:UniProtKB-KW
Interpro
InterPro; IPR000961; AGC-kinase_C
InterPro; IPR000239; GPCR_kinase
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR016137; Regulat_G_prot_signal_superfam
InterPro; IPR000342; RGS_dom
InterPro; IPR002290; Ser/Thr_dual-sp_kinase
InterPro; IPR008271; Ser/Thr_kinase_AS
Pfam
Pfam; PF00069; Pkinase;
Pfam; PF00615; RGS;
SMART
SMART; SM00315; RGS;
SMART; SM00133; S_TK_X;
SMART; SM00220; S_TKc;
PROSITE
PROSITE; PS51285; AGC_KINASE_CTER;
PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;
PROSITE; PS00108; PROTEIN_KINASE_ST;
PROSITE; PS50132; RGS;
PRINTS
PRINTS; PR00717; GPCRKINASE;