Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9913-00005
Entry Name
UniProt Accession
Theoretical PI
8.71
Molecular Weight
30015.1
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Myelin proteolipid protein
Protein Synonyms/Alias
PLP; Lipophilin;
Gene Name
PLP1
Gene Synonyms/Alias
PLP;
Created Date
01-NOV-1986
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
6
Canonical
**MGLLECCARCLVG
[1]
S-Palmitoylation
7
Canonical
*MGLLECCARCLVGA
[1]
S-Palmitoylation
10
Canonical
LLECCARCLVGAPFA
[1]
S-Palmitoylation
109
Canonical
GDYKTTICGKGLSAT
[1][2]
S-Palmitoylation
139
Canonical
AHSLERVCHCLGKWL
[1]
S-Palmitoylation
141
Canonical
SLERVCHCLGKWLGH
[1]
S-Palmitoylation
Organism
Bos taurus (Bovine)
NCBI Taxa ID
9913
Reference
[1] Weimbs T, Stoffel W. Proteolipid protein (PLP) of CNS myelin: positions offree, disulfide-bonded, and fatty acid thioester-linked cysteine residues andimplications for the membrane topology of PLP. Biochemistry. 1992 Dec15;31(49):12289-96.[PMID:1281423]
[2] Bizzozero OA, Good LK, Evans JE. Cysteine-108 is an acylation site in myelinproteolipid protein. Biochem Biophys Res Commun. 1990 Jul 16;170(1):375-82.[PMID:1695508]
Functional Description
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Sequence Annotation
Topological domain: 2 10 Cytoplasmic.
Transmembrane: 11 36 Helical; Name=1.
Topological domain: 37 59 Extracellular.
Transmembrane: 60 88 Helical; Name=2.
Topological domain: 89 151 Cytoplasmic.
Transmembrane: 152 178 Helical; Name=3.
Topological domain: 179 238 Extracellular.
Transmembrane: 239 268 Helical; Name=4.
Topological domain: 269 277 Cytoplasmic.
Protein Length
277 AA.
Protein Sequence
(Canonical)
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY FSKNYQDYEY  60
LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI FGDYKTTICG KGLSATVTGG  120
QKGRGSRGQH QAHSLERVCH CLGKWLGHPD KFVGITYALT VVWLLVFACS AVPVYIYFNT  180
WTTCQSIAAP SKTSASIGTL CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF  240
IAAFVGAAAT LVSLLTFMIA ATYNFAVLKL MGRGTKF                           277
FASTA
(Canonical)
>LipidDB-9913-00005|P04116
MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEY
LINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGG
QKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNT
WTTCQSIAAPSKTSASIGTLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLF
IAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0043209; C:myelin sheath; IEA:Ensembl
GO:0005886; C:plasma membrane; ISS:UniProtKB
GO:0014002; P:astrocyte development; IEA:Ensembl
GO:0061564; P:axon development; IEA:Ensembl
GO:0048469; P:cell maturation; IEA:Ensembl
GO:0022010; P:central nervous system myelination; IEA:Ensembl
GO:0006954; P:inflammatory response; IEA:Ensembl
GO:0042759; P:long-chain fatty acid biosynthetic process; IEA:Ensembl
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl
GO:0021762; P:substantia nigra development; IEA:Ensembl
Interpro
InterPro; IPR001614; Myelin_PLP
InterPro; IPR018237; Myelin_PLP_CS
Pfam
Pfam; PF01275; Myelin_PLP;
SMART
SMART; SM00002; PLP;
PROSITE
PROSITE; PS00575; MYELIN_PLP_1;
PROSITE; PS01004; MYELIN_PLP_2;
PRINTS
PRINTS; PR00214; MYELINPLP;