LipidDB ID

LipidDB-9823-01077

Entry Name

UniProt Accession

P15785;

Theoretical PI

9.7

Molecular Weight

3709.87

Genbank Protein ID

Genbank Nucleotide ID

Protein Name

Pulmonary surfactant-associated protein C

Protein Synonyms/Alias

SP-C; Pulmonary surfactant-associated proteolipid SPL(Val);

Gene Name

SFTPC

Gene Synonyms/Alias

SFTP2;

Created Date

01-APR-1990

Organism

Sus scrofa (Pig)

NCBI Taxa ID

9823

Reference

[1] Curstedt T, Johansson J, Persson P, Eklund A, Robertson B, Löwenadler B,Jörnvall H. Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptidewith two palmitoylated cysteine residues, whereas SP-B lacks covalently linkedfatty acyl groups. Proc Natl Acad Sci U S A. 1990 Apr;87(8):2985-9.[PMID:2326260]
[2] Baumgart F, Ospina OL, Mingarro I, Rodríguez-Crespo I, Pérez-Gil J.Palmitoylation of pulmonary surfactant protein SP-C is critical for itsfunctional cooperation with SP-B to sustain compression/expansion dynamics incholesterol-containing surfactant films. Biophys J. 2010 Nov 17;99(10):3234-43.doi: 10.1016/j.bpj.2010.08.070.[PMID:21081071]

Functional Description

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces.

Sequence Annotation

Protein Length

35 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IEA:Ensembl
GO:0005576; C:extracellular region; IEA:UniProtKB-KW
GO:0007585; P:respiratory gaseous exchange; IEA:UniProtKB-KW

Interpro

InterPro; IPR018051; SP-C_palmitoylation_site
InterPro; IPR015091; Surfactant_protein_propep

Pfam

Pfam; PF08999; SP_C-Propep;

SMART

PROSITE

PROSITE; PS00341; SURFACT_PALMITOYL;

PRINTS