Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9615-01367
Entry Name
UniProt Accession
Theoretical PI
5.65
Molecular Weight
20605.75
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Caveolin-1
Protein Synonyms/Alias
Vesicular integral-membrane protein VIP21;
Gene Name
CAV1
Gene Synonyms/Alias
CAV;
Created Date
01-FEB-1994
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
133
Canonical
HIWAVVPCIKSFLIE
[1]
S-Palmitoylation
143
Canonical
SFLIEIQCISRVYSI
[1]
S-Palmitoylation
156
Canonical
SIYVHTFCDPFFEAV
[1]
S-Palmitoylation
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
NCBI Taxa ID
9615
Reference
[1] Dietzen DJ, Hastings WR, Lublin DM. Caveolin is palmitoylated on multiplecysteine residues. Palmitoylation is not necessary for localization of caveolinto caveolae. J Biol Chem. 1995 Mar 24;270(12):6838-42.[PMID:7896831]
Functional Description
Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
Sequence Annotation
Topological domain: 2 104 Cytoplasmic.
Topological domain: 126 178 Cytoplasmic.
Modified residue: 2 2 N-acetylserine.
Modified residue: 5 5 N6-acetyllysine.
Modified residue: 6 6 Phosphotyrosine.
Modified residue: 14 14 Phosphotyrosine; by ABL1.
Modified residue: 25 25 Phosphotyrosine.
Modified residue: 37 37 Phosphoserine.
Modified residue: 42 42 Phosphotyrosine.
Protein Length
178 AA.
Protein Sequence
(Canonical)
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMSEKQ VYDAHTKEID LVNRDPKHLN  60
DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA  120
ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPFF EAVGKIFSNI RINMQKET    178
FASTA
(Canonical)
>LipidDB-9615-01367|P33724
MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMAEEMSEKQVYDAHTKEIDLVNRDPKHLN
DDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFA
ILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPFFEAVGKIFSNIRINMQKET
Gene Ontology
GO:0002080; C:acrosomal membrane; IEA:Ensembl
GO:0016324; C:apical plasma membrane; IEA:Ensembl
GO:0016323; C:basolateral plasma membrane; IEA:Ensembl
GO:0005901; C:caveola; IDA:UniProtKB
GO:0005938; C:cell cortex; IEA:Ensembl
GO:0005929; C:cilium; IEA:Ensembl
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl
GO:0005768; C:endosome; ISS:UniProtKB
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl
GO:0043234; C:protein complex; IEA:Ensembl
GO:0016504; F:peptidase activator activity; IEA:Ensembl
GO:0005198; F:structural molecule activity; IDA:UniProtKB
GO:0001525; P:angiogenesis; IEA:Ensembl
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl
GO:0006816; P:calcium ion transport; IEA:Ensembl
GO:0070836; P:caveola assembly; IEA:Ensembl
GO:0072584; P:caveolin-mediated endocytosis; IEA:Ensembl
GO:0071455; P:cellular response to hyperoxia; IEA:Ensembl
GO:0009267; P:cellular response to starvation; IEA:Ensembl
GO:0042632; P:cholesterol homeostasis; IEA:Ensembl
GO:0051480; P:cytosolic calcium ion homeostasis; IEA:Ensembl
GO:0000188; P:inactivation of MAPK activity; IEA:Ensembl
GO:0007595; P:lactation; IEA:Ensembl
GO:0019915; P:lipid storage; IEA:Ensembl
GO:0060056; P:mammary gland involution; IEA:Ensembl
GO:0000165; P:MAPK cascade; IEA:Ensembl
GO:0051899; P:membrane depolarization; IEA:Ensembl
GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl
GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl
GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl
GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl
GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IEA:Ensembl
GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Ensembl
GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl
GO:0048550; P:negative regulation of pinocytosis; IEA:Ensembl
GO:0032091; P:negative regulation of protein binding; IEA:Ensembl
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0042524; P:negative regulation of tyrosine phosphorylation of Stat5 protein; IEA:Ensembl
GO:0033484; P:nitric oxide homeostasis; IEA:Ensembl
GO:0010524; P:positive regulation of calcium ion transport into cytosol; IEA:Ensembl
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl
GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl
GO:0048554; P:positive regulation of metalloenzyme activity; IEA:Ensembl
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl
GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl
GO:0051260; P:protein homooligomerization; IEA:Ensembl
GO:0008104; P:protein localization; IEA:Ensembl
GO:2000286; P:receptor internalization involved in canonical Wnt signaling pathway; IEA:Ensembl
GO:0030193; P:regulation of blood coagulation; IEA:Ensembl
GO:0019217; P:regulation of fatty acid metabolic process; IEA:Ensembl
GO:0006940; P:regulation of smooth muscle contraction; IEA:Ensembl
GO:0003057; P:regulation of the force of heart contraction by chemical signal; IEA:Ensembl
GO:0051592; P:response to calcium ion; IEA:Ensembl
GO:0043627; P:response to estrogen; IEA:Ensembl
GO:0001666; P:response to hypoxia; IEA:Ensembl
GO:0002931; P:response to ischemia; IEA:Ensembl
GO:0032570; P:response to progesterone; IEA:Ensembl
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl
GO:0031295; P:T cell costimulation; ISS:UniProtKB
GO:0006641; P:triglyceride metabolic process; IEA:Ensembl
GO:0001570; P:vasculogenesis; IEA:Ensembl
GO:0042310; P:vasoconstriction; IEA:Ensembl
GO:0016050; P:vesicle organization; IEA:Ensembl
Interpro
InterPro; IPR001612; Caveolin
InterPro; IPR015504; Caveolin_1
InterPro; IPR018361; Caveolin_CS
Pfam
Pfam; PF01146; Caveolin;
SMART
PROSITE
PROSITE; PS01210; CAVEOLIN;
PRINTS