LipidDB-9615-00860

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9615-00860

Entry Name

HRH2_CANFA

UniProt Accession

P17124;

Theoretical PI

9.31

Molecular Weight

40201.21

Genbank Protein ID

AAA85637.1;

Genbank Nucleotide ID

M32701;

Protein Name

Histamine H2 receptor

Protein Synonyms/Alias

H2R; HH2R; Gastric receptor I;

Gene Name

HRH2

Gene Synonyms/Alias

Created Date

01-AUG-1990

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
305	Canonical	AYQQLFRCRPASHNA	[1]	S-Palmitoylation

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

NCBI Taxa ID

9615

Reference

[1] Fukushima Y, Saitoh T, Anai M, Ogihara T, Inukai K, Funaki M, Sakoda H, OnishiY, Ono H, Fujishiro M, Ishikawa T, Takata K, Nagai R, Omata M, Asano T.Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and isimportant for cell surface targeting. Biochim Biophys Acta. 2001 Jun20;1539(3):181-91.[PMID:11420116]

Functional Description

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Sequence Annotation

Topological domain: 1 22 Extracellular.
Transmembrane: 23 44 Helical; Name=1.
Topological domain: 45 57 Cytoplasmic.
Transmembrane: 58 81 Helical; Name=2.
Topological domain: 82 92 Extracellular.
Transmembrane: 93 114 Helical; Name=3.
Topological domain: 115 134 Cytoplasmic.
Transmembrane: 135 159 Helical; Name=4.
Topological domain: 160 180 Extracellular.
Transmembrane: 181 204 Helical; Name=5.
Topological domain: 205 234 Cytoplasmic.
Transmembrane: 235 258 Helical; Name=6.
Topological domain: 259 267 Extracellular.
Transmembrane: 268 289 Helical; Name=7.
Topological domain: 290 359 Cytoplasmic.
Functional site: 98 98 Essential for histamine binding.
Functional site: 186 186 Essential for tiotidine binding and H2selectivity.
Functional site: 190 190 Implicated in histamine binding.

Protein Length

359 AA.

Protein Sequence
(Canonical)

MISNGTGSSF CLDSPPCRIT VSVVLTVLIL ITIAGNVVVC LAVGLNRRLR SLTNCFIVSL  60
AITDLLLGLL VLPFSAFYQL SCRWSFGKVF CNIYTSLDVM LCTASILNLF MISLDRYCAV  120
TDPLRYPVLI TPVRVAVSLV LIWVISITLS FLSIHLGWNS RNETSSFNHT IPKCKVQVNL  180
VYGLVDGLVT FYLPLLVMCI TYYRIFKIAR DQAKRIHHMG SWKAATIGEH KATVTLAAVM  240
GAFIICWFPY FTVFVYRGLK GDDAINEAFE AVVLWLGYAN SALNPILYAT LNRDFRTAYQ  300
QLFRCRPASH NAQETSLRSN SSQLARNQSR EPMRQEEKPL KLQVWSGTEV TAPRGATDR   359

FASTA
(Canonical)

>LipidDB-9615-00860|P17124
MISNGTGSSFCLDSPPCRITVSVVLTVLILITIAGNVVVCLAVGLNRRLRSLTNCFIVSL
AITDLLLGLLVLPFSAFYQLSCRWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPVRVAVSLVLIWVISITLSFLSIHLGWNSRNETSSFNHTIPKCKVQVNL
VYGLVDGLVTFYLPLLVMCITYYRIFKIARDQAKRIHHMGSWKAATIGEHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAINEAFEAVVLWLGYANSALNPILYATLNRDFRTAYQ
QLFRCRPASHNAQETSLRSNSSQLARNQSREPMRQEEKPLKLQVWSGTEVTAPRGATDR

Gene Ontology

GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004969; F:histamine receptor activity; IEA:InterPro
GO:0048565; P:digestive tract development; IEA:Ensembl
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl
GO:0001698; P:gastrin-induced gastric acid secretion; IEA:Ensembl
GO:0048732; P:gland development; IEA:Ensembl
GO:0001697; P:histamine-induced gastric acid secretion; IEA:Ensembl
GO:0007613; P:memory; IEA:Ensembl
GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl
GO:0008542; P:visual learning; IEA:Ensembl

Interpro

InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR000503; Histamine_H2_rcpt

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR00531; HISTAMINEH2R;