LipidDB ID

LipidDB-9615-00436

Entry Name

UniProt Accession

P62822; P05711;

Theoretical PI

5.93

Molecular Weight

22677.75

Genbank Protein ID

CAB56775.1;

Genbank Nucleotide ID

X56384;

Protein Name

Ras-related protein Rab-1A

Protein Synonyms/Alias

Gene Name

RAB1A

Gene Synonyms/Alias

RAB1;

Created Date

16-AUG-2004

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

NCBI Taxa ID

9615

Reference

[1] Khosravi-Far R, Lutz RJ, Cox AD, Conroy L, Bourne JR, Sinensky M, Balch WE,Buss JE, Der CJ. Isoprenoid modification of rab proteins terminating in CC or CXCmotifs. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6264-8.[PMID:1648736]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

Sequence Annotation

Nucleotide-binding: 18 26 GTP.
Nucleotide-binding: 36 43 GTP.
Nucleotide-binding: 66 70 GTP.
Nucleotide-binding: 124 127 GTP.
Nucleotide-binding: 154 156 GTP.
Motif: 40 48 Effector region.
Modified residue: 2 2 N-acetylserine.
Modified residue: 79 79 O-(2-cholinephosphoryl)serine.

Protein Length

205 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; ISS:UniProtKB
GO:0000045; P:autophagic vacuole assembly; ISS:UniProtKB
GO:0006914; P:autophagy; ISS:UniProtKB
GO:0016477; P:cell migration; ISS:UniProtKB
GO:0042742; P:defense response to bacterium; ISS:UniProtKB
GO:0006897; P:endocytosis; ISS:UniProtKB
GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:UniProtKB
GO:0030252; P:growth hormone secretion; ISS:UniProtKB
GO:0006184; P:GTP catabolic process; ISS:UniProtKB
GO:0072606; P:interleukin-8 secretion; ISS:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0047496; P:vesicle transport along microtubule; ISS:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;