LipidDB ID

LipidDB-9606-01478

Entry Name

UniProt Accession

P21554; B2R9T4; E1P512; Q13949; Q495Z0; Q4PLI4; Q4VBM6; Q5JVL5; Q5UB37; Q9UNN0;

Theoretical PI

8.47

Molecular Weight

52857.95

Genbank Protein ID

CAA38699.1; CAA57018.1; CAA57019.1; AAV35030.1; AAD34320.1; AAB18200.1; AAY68486.1; AAO67710.1; CAB96726.1; CAI19916.1; BAG36631.1; EAW48574.1; EAW48575.1; EAW48576.1; AAH74811.1; AAH74812.1; AAH95513.1; AAI00969.1; AAI00970.1; AAI00971.1; AAI00972.1;

Genbank Nucleotide ID

X54937; X81120; X81121; AY766182; AF107262; U73304; DQ067455; AY225225; AL136096; AL136096; AK313908; CH471051; CH471051; CH471051; BC074811; BC074812; BC095513; BC100968; BC100969; BC100970; BC100971;

Protein Name

Cannabinoid receptor 1

Protein Synonyms/Alias

CB-R; CB1; CANN6;

Gene Name

CNR1

Gene Synonyms/Alias

CNR;

Created Date

01-MAY-1991

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Oddi S, Dainese E, Sandiford S, Fezza F, Lanuti M, Chiurchiù V, Totaro A,Catanzaro G, Barcaroli D, De Laurenzi V, Centonze D, Mukhopadhyay S, Selent J,Howlett AC, Maccarrone M. Effects of palmitoylation of Cys(415) in helix 8 of theCB(1) cannabinoid receptor on membrane localization and signalling. Br JPharmacol. 2012 Apr;165(8):2635-51. doi: 10.1111/j.1476-5381.2011.01658.x. PubMedPMID: 21895628; PubMed Central PMCID: PMC3423250.[PMID:21895628]

Functional Description

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.

Sequence Annotation

Topological domain: 1 116 Extracellular.
Transmembrane: 117 142 Helical; Name=1.
Topological domain: 143 154 Cytoplasmic.
Transmembrane: 155 175 Helical; Name=2.
Topological domain: 176 187 Extracellular.
Transmembrane: 188 212 Helical; Name=3.
Topological domain: 213 232 Cytoplasmic.
Transmembrane: 233 255 Helical; Name=4.
Topological domain: 256 273 Extracellular.
Transmembrane: 274 299 Helical; Name=5.
Topological domain: 300 344 Cytoplasmic.
Transmembrane: 345 365 Helical; Name=6.
Topological domain: 366 377 Extracellular.
Transmembrane: 378 399 Helical; Name=7.
Topological domain: 400 472 Cytoplasmic.

Protein Length

472 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004949; F:cannabinoid receptor activity; IDA:UniProtKB
GO:0008144; F:drug binding; IEA:Ensembl
GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IDA:UniProtKB
GO:0007568; P:aging; IEA:Ensembl
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc
GO:0042593; P:glucose homeostasis; IEA:Ensembl
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl
GO:0007613; P:memory; IEA:Ensembl
GO:0045759; P:negative regulation of action potential; IEA:Ensembl
GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl
GO:0033602; P:negative regulation of dopamine secretion; IEA:Ensembl
GO:0031999; P:negative regulation of fatty acid beta-oxidation; IEA:Ensembl
GO:0033004; P:negative regulation of mast cell activation; IEA:Ensembl
GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Ensembl
GO:0002866; P:positive regulation of acute inflammatory response to antigenic stimulus; IEA:Ensembl
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl
GO:0045777; P:positive regulation of blood pressure; IEA:Ensembl
GO:0031622; P:positive regulation of fever generation; IEA:Ensembl
GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl
GO:0060259; P:regulation of feeding behavior; IEA:Ensembl
GO:0050796; P:regulation of insulin secretion; IEA:Ensembl
GO:0060405; P:regulation of penile erection; IEA:Ensembl
GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl
GO:0042220; P:response to cocaine; IEA:Ensembl
GO:0045471; P:response to ethanol; IEA:Ensembl
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl
GO:0043278; P:response to morphine; IEA:Ensembl
GO:0035094; P:response to nicotine; IEA:Ensembl
GO:0007584; P:response to nutrient; IEA:Ensembl
GO:0019233; P:sensory perception of pain; IEA:Ensembl
GO:0007283; P:spermatogenesis; IEA:Ensembl

Interpro

InterPro; IPR000810; Canbinoid_rcpt_1
InterPro; IPR002230; Cnbnoid_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00522; CANABINOID1R;
PRINTS; PR00362; CANNABINOIDR;
PRINTS; PR00237; GPCRRHODOPSN;