Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01469
Entry Name
UniProt Accession
Theoretical PI
8.82
Molecular Weight
78642.97
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Lutropin-choriogonadotropic hormone receptor
Protein Synonyms/Alias
LH/CG-R; Luteinizing hormone receptor; LHR; LSH-R;
Gene Name
LHCGR
Gene Synonyms/Alias
LCGR; LGR2; LHRHR;
Created Date
01-AUG-1991
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
643
Canonical
LLLSKFGCCKRRAEL
[1]
S-Palmitoylation
644
Canonical
LLSKFGCCKRRAELY
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Munshi UM, Clouser CL, Peegel H, Menon KM. Evidence that palmitoylation ofcarboxyl terminus cysteine residues of the human luteinizing hormone receptorregulates postendocytic processing. Mol Endocrinol. 2005 Mar;19(3):749-58. Epub2004 Nov 11.[PMID:15539429]
Functional Description
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Sequence Annotation
Topological domain: 27 363 Extracellular.
Transmembrane: 364 385 Helical; Name=1.
Topological domain: 386 395 Cytoplasmic.
Transmembrane: 396 416 Helical; Name=2.
Topological domain: 417 439 Extracellular.
Transmembrane: 440 462 Helical; Name=3.
Topological domain: 463 482 Cytoplasmic.
Transmembrane: 483 505 Helical; Name=4.
Topological domain: 506 525 Extracellular.
Transmembrane: 526 549 Helical; Name=5.
Topological domain: 550 570 Cytoplasmic.
Transmembrane: 571 594 Helical; Name=6.
Topological domain: 595 605 Extracellular.
Transmembrane: 606 627 Helical; Name=7.
Topological domain: 628 699 Cytoplasmic.
Domain: 27 66 LRRNT.
Protein Length
699 AA.
Protein Sequence
(Canonical)
MKQRFSALQL LKLLLLLQPP LPRALREALC PEPCNCVPDG ALRCPGPTAG LTRLSLAYLP  60
VKVIPSQAFR GLNEVIKIEI SQIDSLERIE ANAFDNLLNL SEILIQNTKN LRYIEPGAFI  120
NLPRLKYLSI CNTGIRKFPD VTKVFSSESN FILEICDNLH ITTIPGNAFQ GMNNESVTLK  180
LYGNGFEEVQ SHAFNGTTLT SLELKENVHL EKMHNGAFRG ATGPKTLDIS STKLQALPSY  240
GLESIQRLIA TSSYSLKKLP SRETFVNLLE ATLTYPSHCC AFRNLPTKEQ NFSHSISENF  300
SKQCESTVRK VNNKTLYSSM LAESELSGWD YEYGFCLPKT PRCAPEPDAF NPCEDIMGYD  360
FLRVLIWLIN ILAIMGNMTV LFVLLTSRYK LTVPRFLMCN LSFADFCMGL YLLLIASVDS  420
QTKGQYYNHA IDWQTGSGCS TAGFFTVFAS ELSVYTLTVI TLERWHTITY AIHLDQKLRL  480
RHAILIMLGG WLFSSLIAML PLVGVSNYMK VSICFPMDVE TTLSQVYILT ILILNVVAFF  540
IICACYIKIY FAVRNPELMA TNKDTKIAKK MAILIFTDFT CMAPISFFAI SAAFKVPLIT  600
VTNSKVLLVL FYPINSCANP FLYAIFTKTF QRDFFLLLSK FGCCKRRAEL YRRKDFSAYT  660
SNCKNGFTGS NKPSQSTLKL STLHCQGTAL LDKTRYTEC                         699
FASTA
(Canonical)
>LipidDB-9606-01469|P22888
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLP
VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI
NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK
LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY
GLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENF
SKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYD
FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS
QTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRL
RHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFF
IICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT
VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYT
SNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
Gene Ontology
GO:0005768; C:endosome; TAS:ProtInc
GO:0005887; C:integral component of plasma membrane; ISS:BHF-UCL
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0038106; F:choriogonadotropin hormone binding; ISS:BHF-UCL
GO:0035472; F:choriogonadotropin hormone receptor activity; ISS:BHF-UCL
GO:0004964; F:luteinizing hormone receptor activity; IEA:InterPro
GO:0007190; P:activation of adenylate cyclase activity; ISS:BHF-UCL
GO:0071371; P:cellular response to gonadotropin stimulus; ISS:BHF-UCL
GO:0050890; P:cognition; IMP:UniProt
GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc
GO:0030539; P:male genitalia development; TAS:ProtInc
GO:0008584; P:male gonad development; TAS:ProtInc
GO:0001541; P:ovarian follicle development; IEA:Ensembl
GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; ISS:BHF-UCL
GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:BHF-UCL
GO:0032962; P:positive regulation of inositol trisphosphate biosynthetic process; ISS:BHF-UCL
GO:0090030; P:regulation of steroid hormone biosynthetic process; IEA:Ensembl
GO:0072520; P:seminiferous tubule development; IEA:Ensembl
GO:0007283; P:spermatogenesis; IEA:Ensembl
GO:0060065; P:uterus development; IEA:Ensembl
Interpro
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR002131; Gphrmn_rcpt_fam
InterPro; IPR000372; LRR-contain_N
InterPro; IPR026906; LRR_5
InterPro; IPR002273; LSH_rcpt
Pfam
Pfam; PF00001; 7tm_1;
Pfam; PF13306; LRR_5;
SMART
SMART; SM00013; LRRNT;
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00373; GLYCHORMONER;
PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR01144; LSHRECEPTOR;