| Tag |
Content |
LipidDB ID |
LipidDB-9606-01466 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.88 |
Molecular Weight |
32004.46 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Serine/threonine-protein phosphatase PGAM5, mitochondrial |
Protein Synonyms/Alias |
3.1.3.16; Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5; |
Gene Name |
PGAM5 |
Gene Synonyms/Alias |
|
Created Date |
29-MAY-2007 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
12 | Canonical | QALQLAACGLAGGSA | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. |
Sequence Annotation |
Transmembrane: 7 29 Helical.
Region: 77 82 Interaction with KEAP1.
Modified residue: 80 80 Phosphoserine.
Modified residue: 116 116 N6-acetyllysine.
Modified residue: 144 144 N6-acetyllysine.
Modified residue: 191 191 N6-acetyllysine.
|
Protein Length |
289 AA. |
Protein Sequence
(Canonical) |
MAFRQALQLA ACGLAGGSAA VLFSAVAVGK PRAGGDAEPR PAEPPAWAGG ARPGPGVWDP 60
NWDRREPLSL INVRKRNVES GEEELASKLD HYKAKATRHI FLIRHSQYHV DGSLEKDRTL 120
TPLGREQAEL TGLRLASLGL KFNKIVHSSM TRAIETTDII SRHLPGVCKV STDLLREGAP 180
IEPDPPVSHW KPEAVQYYED GARIEAAFRN YIHRADARQE EDSYEIFICH ANVIRYIVCR 240
ALQFPPEGWL RLSLNNGSIT HLVIRPNGRV ALRTLGDTGF MPPDKITRS 289
|
FASTA
(Canonical) |
>LipidDB-9606-01466|Q96HS1
MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDAEPRPAEPPAWAGGARPGPGVWDP
NWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTL
TPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAP
IEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCR
ALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
|
Gene Ontology |
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-KW GO:0005739; C:mitochondrion; IDA:HPA GO:0005096; F:GTPase activator activity; IMP:UniProtKB GO:0016791; F:phosphatase activity; IMP:UniProtKB GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-EC GO:0032403; F:protein complex binding; IDA:UniProtKB GO:0016311; P:dephosphorylation; IMP:GOC GO:0070266; P:necroptotic process; IMP:UniProtKB GO:0043547; P:positive regulation of GTPase activity; IMP:GOC |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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