LipidDB ID

LipidDB-9606-01458

Entry Name

UniProt Accession

Q6IAA8; Q8WZ09; Q9NWT0;

Theoretical PI

5.01

Molecular Weight

17744.82

Genbank Protein ID

AAL55767.1; CAG33528.1; BAA91297.1; AAH01706.1;

Genbank Nucleotide ID

AF289583; CR457247; AK000632; BC001706;

Protein Name

Ragulator complex protein LAMTOR1

Protein Synonyms/Alias

Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; Protein associated with DRMs and endosomes; p27Kip1-releasing factor from RhoA; p27RF-Rho;

Gene Name

LAMTOR1

Gene Synonyms/Alias

C11orf59; PDRO; PP7157;

Created Date

06-FEB-2007

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Sequence Annotation

Region: 121 161 Interaction with LAMTOR2 and LAMTOR3.
Modified residue: 27 27 Phosphoserine.

Protein Length

161 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:HPA
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA
GO:0031902; C:late endosome membrane; ISS:UniProtKB
GO:0005764; C:lysosome; IDA:UniProtKB
GO:0045121; C:membrane raft; ISS:UniProtKB
GO:0005886; C:plasma membrane; IDA:HPA
GO:0071986; C:Ragulator complex; IDA:UniProtKB
GO:0016049; P:cell growth; IMP:UniProtKB
GO:0034613; P:cellular protein localization; IMP:UniProtKB
GO:0071230; P:cellular response to amino acid stimulus; IMP:UniProtKB
GO:0042632; P:cholesterol homeostasis; IMP:UniProtKB
GO:0032439; P:endosome localization; ISS:UniProtKB
GO:0007032; P:endosome organization; ISS:UniProtKB
GO:0032418; P:lysosome localization; ISS:UniProtKB
GO:0007040; P:lysosome organization; ISS:UniProtKB
GO:0043547; P:positive regulation of GTPase activity; IDA:GOC
GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB
GO:0032008; P:positive regulation of TOR signaling; IMP:UniProtKB
GO:0010874; P:regulation of cholesterol efflux; IMP:UniProtKB
GO:0010872; P:regulation of cholesterol esterification; IMP:UniProtKB
GO:0060620; P:regulation of cholesterol import; IMP:UniProtKB
GO:0001919; P:regulation of receptor recycling; ISS:UniProtKB

Interpro

InterPro; IPR026310; LAMTOR1-like
InterPro; IPR028209; LAMTOR1/MEH1

Pfam

Pfam; PF15454; LAMTOR;

SMART

PROSITE

PRINTS