Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01454
Entry Name
UniProt Accession
Theoretical PI
6.47
Molecular Weight
166367.23
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Glutamate receptor ionotropic, NMDA 2B
Protein Synonyms/Alias
GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3;
Gene Name
GRIN2B
Gene Synonyms/Alias
NMDAR2B;
Created Date
20-JUN-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
849
Canonical
FYWQFRHCFMGVCSG
[1]
S-Palmitoylation
854
Canonical
RHCFMGVCSGKPGMV
[1]
S-Palmitoylation
871
Canonical
ISRGIYSCIHGVAIE
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Hayashi T, Thomas GM, Huganir RL. Dual palmitoylation of NR2 subunitsregulates NMDA receptor trafficking. Neuron. 2009 Oct 29;64(2):213-26. doi:10.1016/j.neuron.2009.08.017.[PMID:19874789]
Functional Description
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Sequence Annotation
Topological domain: 27 557 Extracellular.
Transmembrane: 558 578 Helical.
Topological domain: 579 634 Cytoplasmic.
Transmembrane: 635 655 Helical.
Topological domain: 656 817 Extracellular.
Transmembrane: 818 838 Helical.
Topological domain: 839 1484 Cytoplasmic.
Region: 1292 1304 Interaction with DAPK1.
Motif: 1482 1484 PDZ-binding.
Metal binding site: 127 127 Zinc.
Metal binding site: 284 284 Zinc.
Functional site: 615 615 Functional determinant of NMDA receptors.
Modified residue: 962 962 Phosphotyrosine.
Modified residue: 1039 1039 Phosphotyrosine.
Modified residue: 1109 1109 Phosphotyrosine.
Modified residue: 1133 1133 Phosphotyrosine.
Modified residue: 1155 1155 Phosphotyrosine.
Modified residue: 1303 1303 Phosphoserine; by DAPK1.
Modified residue: 1474 1474 Phosphotyrosine.
Protein Length
1484 AA.
Protein Sequence
(Canonical)
MKPRAECCSP KFWLVLAVLA VSGSRARSQK SPPSIGIAVI LVGTSDEVAI KDAHEKDDFH  60
HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA DDTDQEAIAQ ILDFISAQTL  120
TPILGIHGGS SMIMADKDES SMFFQFGPSI EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ  180
DFVNKIRSTI ENSFVGWELE EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI  240
FEVANSVGLT GYGYTWIVPS LVAGDTDTVP AEFPTGLISV SYDEWDYGLP ARVRDGIAII  300
TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS FSEDGYQMHP  360
KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE QEDDHLSIVT LEEAPFVIVE  420
SVDPLSGTCM RNTVPCQKRI VTENKTDEEP GYIKKCCKGF CIDILKKISK SVKFTYDLYL  480
VTNGKHGKKI NGTWNGMIGE VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR  540
SNGTVSPSAF LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF  600
TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL AAFMIQEEYV  660
DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA EMHAYMGKFN QRGVDDALLS  720
LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT IGSGKVFAST GYGIAIQKDS GWKRQVDLAI  780
LQLFGDGEME ELEALWLTGI CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH  840
LFYWQFRHCF MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR  900
LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN NPPCEENLFS  960
DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSASSI DGLYDCDNPP FTTQSRSISK  1020
KPLDIGLPSS KHSQLSDLYG KFSFKSDRYS GHDDLIRSDV SDISTHTVTY GNIEGNAAKR  1080
RKQQYKDSLK KRPASAKSRR EFDEIELAYR RRPPRSPDHK RYFRDKEGLR DFYLDQFRTK  1140
ENSPHWEHVD LTDIYKERSD DFKRDSVSGG GPCTNRSHIK HGTGDKHGVV SGVPAPWEKN  1200
LTNVEWEDRS GGNFCRSCPS KLHNYSTTVT GQNSGRQACI RCEACKKAGN LYDISEDNSL  1260
QELDQPAAPV AVTSNASTTK YPQSPTNSKA QKKNRNKLRR QHSYDTFVDL QKEEAALAPR  1320
SVSLKDKGRF MDGSPYAHMF EMSAGESTFA NNKSSVPTAG HHHHNNPGGG YMLSKSLYPD  1380
RVTQNPFIPT FGDDQCLLHG SKSYFFRQPT VAGASKARPD FRALVTNKPV VSALHGAVPA  1440
RFQKDICIGN QSNPCVPNNK NPRAFNGSSN GHVYEKLSSI ESDV                   1484
FASTA
(Canonical)
>LipidDB-9606-01454|Q13224
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
Gene Ontology
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0009986; C:cell surface; ISS:BHF-UCL
GO:0030425; C:dendrite; IBA:RefGenome
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IDA:UniProtKB
GO:0043005; C:neuron projection; ISS:BHF-UCL
GO:0097481; C:neuronal postsynaptic density; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0045211; C:postsynaptic membrane; IBA:RefGenome
GO:0008021; C:synaptic vesicle; IEA:Ensembl
GO:0005262; F:calcium channel activity; IEA:Ensembl
GO:0005234; F:extracellular-glutamate-gated ion channel activity; IBA:RefGenome
GO:0016594; F:glycine binding; IDA:UniProtKB
GO:0004972; F:N-methyl-D-aspartate selective glutamate receptor activity; IBA:RefGenome
GO:0008270; F:zinc ion binding; ISS:UniProtKB
GO:0001662; P:behavioral fear response; IEA:Ensembl
GO:0048266; P:behavioral response to pain; IEA:Ensembl
GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl
GO:0007215; P:glutamate receptor signaling pathway; TAS:ProtInc
GO:0001701; P:in utero embryonic development; IEA:Ensembl
GO:0034220; P:ion transmembrane transport; IBA:RefGenome
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IBA:RefGenome
GO:0007612; P:learning; IEA:Ensembl
GO:0007611; P:learning or memory; TAS:ProtInc
GO:0007613; P:memory; IEA:Ensembl
GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Ensembl
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl
GO:0045471; P:response to ethanol; IDA:UniProtKB
GO:0007423; P:sensory organ development; IEA:Ensembl
GO:0001964; P:startle response; IEA:Ensembl
GO:0001967; P:suckling behavior; IEA:Ensembl
GO:0007268; P:synaptic transmission; TAS:Reactome
GO:0035249; P:synaptic transmission, glutamatergic; IBA:RefGenome
GO:0006810; P:transport; TAS:ProtInc
Interpro
InterPro; IPR001828; ANF_lig-bd_rcpt
InterPro; IPR019594; Glu_rcpt_Glu/Gly-bd
InterPro; IPR001320; Iontro_glu_rcpt
InterPro; IPR001508; NMDA_rcpt
InterPro; IPR018884; NMDAR2_C
InterPro; IPR028082; Peripla_BP_I
InterPro; IPR001638; SBP_bac_3
Pfam
Pfam; PF01094; ANF_receptor;
Pfam; PF00060; Lig_chan;
Pfam; PF10565; NMDAR2_C;
Pfam; PF00497; SBP_bac_3;
SMART
SMART; SM00918; Lig_chan-Glu_bd;
SMART; SM00079; PBPe;
PROSITE
PRINTS
PRINTS; PR00177; NMDARECEPTOR;