LipidDB ID

LipidDB-9606-01453

Entry Name

UniProt Accession

Q96QD8; Q6IA88; Q6ZMG2; Q9HAV3; Q9NVA8; Q9P2G5;

Theoretical PI

8.08

Molecular Weight

56026.01

Genbank Protein ID

AAK38510.1; AAG24618.1; CAC51434.1; BAA92620.2; BAA91846.1; BAD18765.1; CAG33548.1; EAW57900.1; EAW57901.1; AAH40342.1;

Genbank Nucleotide ID

AF259799; AF298897; AJ344099; AB037803; AK001700; AK172784; CR457267; CH471111; CH471111; BC040342;

Protein Name

Sodium-coupled neutral amino acid transporter 2

Protein Synonyms/Alias

Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2;

Gene Name

SLC38A2

Gene Synonyms/Alias

ATA2; KIAA1382; SAT2; SNAT2;

Created Date

04-DEC-2007

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta.

Sequence Annotation

Topological domain: 1 76 Cytoplasmic.
Transmembrane: 77 97 Helical.
Topological domain: 98 102 Extracellular.
Transmembrane: 103 123 Helical.
Topological domain: 124 158 Cytoplasmic.
Transmembrane: 159 179 Helical.
Topological domain: 180 188 Extracellular.
Transmembrane: 189 209 Helical.
Topological domain: 210 217 Cytoplasmic.
Transmembrane: 218 238 Helical.
Topological domain: 239 292 Extracellular.
Transmembrane: 293 313 Helical.
Topological domain: 314 329 Cytoplasmic.
Transmembrane: 330 350 Helical.
Topological domain: 351 371 Extracellular.
Transmembrane: 372 392 Helical.
Topological domain: 393 413 Cytoplasmic.
Transmembrane: 414 434 Helical.
Topological domain: 435 436 Extracellular.
Transmembrane: 437 457 Helical.
Topological domain: 458 474 Cytoplasmic.
Transmembrane: 475 495 Helical.
Topological domain: 496 506 Extracellular.
Region: 1 96 Regulates protein turnover upon aminoacid deprivation.
Modified residue: 10 10 Phosphoserine.
Modified residue: 12 12 Phosphoserine.
Modified residue: 22 22 Phosphoserine.
Modified residue: 55 55 Phosphoserine.

Protein Length

506 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0015171; F:amino acid transmembrane transporter activity; IEA:Ensembl
GO:0015293; F:symporter activity; IEA:UniProtKB-KW
GO:0006865; P:amino acid transport; TAS:Reactome
GO:0014047; P:glutamate secretion; TAS:Reactome
GO:0006811; P:ion transport; TAS:Reactome
GO:0007269; P:neurotransmitter secretion; TAS:Reactome
GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW
GO:0007268; P:synaptic transmission; TAS:Reactome
GO:0055085; P:transmembrane transport; TAS:Reactome

Interpro

InterPro; IPR013057; AA_transpt_TM

Pfam

Pfam; PF01490; Aa_trans;

SMART

PROSITE

PRINTS