LipidDB ID

LipidDB-9606-01450

Entry Name

UniProt Accession

Q9UBI6; Q69YP5; Q9BRV5;

Theoretical PI

9.14

Molecular Weight

8006.22

Genbank Protein ID

AAF04571.1; AAP97245.1; AAF17220.1; AAK53385.1; AAM12593.1; BAF85790.1; CAH10645.1; EAX06484.1; EAX06485.1; EAX06486.1; AAH05940.1;

Genbank Nucleotide ID

AF188181; AF123766; AF119663; AF365871; AF493879; AK293101; AL832431; CH471059; CH471059; CH471059; BC005940;

Protein Name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Protein Synonyms/Alias

Gene Name

GNG12

Gene Synonyms/Alias

Created Date

01-DEC-2000

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Morishita R, Nakayama H, Isobe T, Matsuda T, Hashimoto Y, Okano T, Fukada Y,Mizuno K, Ohno S, Kozawa O, et al. Primary structure of a gamma subunit of Gprotein, gamma 12, and its phosphorylation by protein kinase C. J Biol Chem. 1995Dec 8;270(49):29469-75.[PMID:7493986]
[2] Catherman AD, Durbin KR, Ahlf DR, Early BP, Fellers RT, Tran JC, Thomas PM,Kelleher NL. Large-scale top-down proteomics of the human proteome: membraneproteins, mitochondria, and senescence. Mol Cell Proteomics. 2013Dec;12(12):3465-73. doi: 10.1074/mcp.M113.030114. Epub 2013 Sep 10.[PMID:24023390]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Sequence Annotation

Modified residue: 2 2 N-acetylserine.
Modified residue: 26 26 Phosphoserine.
Modified residue: 69 69 Cysteine methyl ester.

Protein Length

72 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0030165; F:PDZ domain binding; IDA:MGI
GO:0042301; F:phosphate ion binding; IEA:Ensembl
GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW
GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome
GO:0021987; P:cerebral cortex development; IEA:Ensembl
GO:0006112; P:energy reserve metabolic process; TAS:Reactome
GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0007268; P:synaptic transmission; TAS:Reactome

Interpro

InterPro; IPR015898; G-protein_gamma-like_dom
InterPro; IPR001770; Gprotein-gamma

Pfam

Pfam; PF00631; G-gamma;

SMART

SMART; SM00224; GGL;

PROSITE

PROSITE; PS50058; G_PROTEIN_GAMMA;

PRINTS

PRINTS; PR00321; GPROTEING;