Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01448
Entry Name
UniProt Accession
Theoretical PI
6.28
Molecular Weight
24669.58
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Acyl-protein thioesterase 1
Protein Synonyms/Alias
APT-1; hAPT1; 3.1.2.-; Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I;
Gene Name
LYPLA1
Gene Synonyms/Alias
APT1; LPL1;
Created Date
16-JAN-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MCGNNMSTP
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Kong E, Peng S, Chandra G, Sarkar C, Zhang Z, Bagh MB, Mukherjee AB. Dynamicpalmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product andgrowth-associated protein-43. J Biol Chem. 2013 Mar 29;288(13):9112-25. doi:10.1074/jbc.M112.421073. Epub 2013 Feb 8.[PMID:23396970]
Functional Description
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.
Sequence Annotation
Active site: 119 119 Charge relay system.
Active site: 174 174 Charge relay system.
Active site: 208 208 Charge relay system.
Modified residue: 224 224 N6-acetyllysine.
Protein Length
230 AA.
Protein Sequence
(Canonical)
MCGNNMSTPL PAIVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIRSSHIK YICPHAPVRP  60
VTLNMNVAMP SWFDIIGLSP DSQEDESGIK QAAENIKALI DQEVKNGIPS NRIILGGFSQ  120
GGALSLYTAL TTQQKLAGVT ALSCWLPLRA SFPQGPIGGA NRDISILQCH GDCDPLVPLM  180
FGSLTVEKLK TLVNPANVTF KTYEGMMHSS CQQEMMDVKQ FIDKLLPPID             230
FASTA
(Canonical)
>LipidDB-9606-01448|O75608
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
Gene Ontology
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0004622; F:lysophospholipase activity; TAS:ProtInc
GO:0008474; F:palmitoyl-(protein) hydrolase activity; IMP:UniProtKB
GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW
GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport; IEA:Ensembl
GO:0046209; P:nitric oxide metabolic process; TAS:Reactome
GO:0002084; P:protein depalmitoylation; IEA:Ensembl
GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome
GO:0044281; P:small molecule metabolic process; TAS:Reactome
Interpro
InterPro; IPR029058; AB_hydrolase
InterPro; IPR003140; PLipase/COase/thioEstase
Pfam
Pfam; PF02230; Abhydrolase_2;
SMART
PROSITE
PRINTS