LipidDB ID

LipidDB-9606-01442

Entry Name

UniProt Accession

P01732; B4DT80; D6W5M8; Q13970; Q4ZG17;

Theoretical PI

9.64

Molecular Weight

25728.99

Genbank Protein ID

AAA79217.1; AAA79217.1; AAA79217.1; AAA79218.1; AAA79218.1; AAA79218.1; AAA61133.1; AAB04637.1; AAA59674.1; BAG61892.1; AAX88864.1; EAW99438.1; EAW99439.1; EAW99440.1;

Genbank Nucleotide ID

M26315; M26313; M26314; M26315; M26313; M26314; M12824; M12828; M27161; AK300089; AC064848; AC112696; CH471053; CH471053; CH471053;

Protein Name

T-cell surface glycoprotein CD8 alpha chain

Protein Synonyms/Alias

T-lymphocyte differentiation antigen T8/Leu-2; CD8a;

Gene Name

CD8A

Gene Synonyms/Alias

MAL;

Created Date

21-JUL-1986

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Pang DJ, Hayday AC, Bijlmakers MJ. CD8 Raft localization is induced by itsassembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers. J BiolChem. 2007 May 4;282(18):13884-94. Epub 2007 Mar 6.[PMID:17341584]

Functional Description

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

Sequence Annotation

Topological domain: 22 182 Extracellular.
Transmembrane: 183 203 Helical.
Topological domain: 204 235 Cytoplasmic.
Domain: 22 135 Ig-like V-type.

Protein Length

235 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009897; C:external side of plasma membrane; IDA:MGI
GO:0005576; C:extracellular region; IEA:UniProtKB-KW
GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0042101; C:T cell receptor complex; NAS:UniProtKB
GO:0015026; F:coreceptor activity; NAS:UniProtKB
GO:0042288; F:MHC class I protein binding; NAS:UniProtKB
GO:0019882; P:antigen processing and presentation; NAS:UniProtKB
GO:0045065; P:cytotoxic T cell differentiation; IEA:Ensembl
GO:0051607; P:defense response to virus; IEA:Ensembl
GO:0006955; P:immune response; NAS:UniProtKB
GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl
GO:0050776; P:regulation of immune response; TAS:Reactome
GO:0042110; P:T cell activation; NAS:UniProtKB
GO:0002456; P:T cell mediated immunity; IEA:Ensembl
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; NAS:UniProtKB

Interpro

InterPro; IPR015468; CD8_asu
InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR013106; Ig_V-set
InterPro; IPR003596; Ig_V-set_subgr

Pfam

Pfam; PF07686; V-set;

SMART

SMART; SM00406; IGv;

PROSITE

PROSITE; PS50835; IG_LIKE;

PRINTS