LipidDB-9606-01434

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-01434

Entry Name

UniProt Accession

Q7Z494; Q5JPE3; Q5JPE6; Q68D99; Q6NVH3; Q7Z492; Q7Z493; Q8N9R2; Q8NCM5; Q96N70; Q96NK2;

Theoretical PI

6.31

Molecular Weight

150864.22

Genbank Protein ID

AAP83423.1; AAP83424.1; AAP83425.1; BAC02709.1; BAB70891.1; BAB71038.1; BAC04268.1; CAI46200.2; CAI46202.1; CAH18321.1; AAH68082.1;

Genbank Nucleotide ID

AY257864; AY257865; AY257866; AB082531; AK055253; AK055893; AK094015; AL832863; AL832877; CR749498; BC068082;

Protein Name

Nephrocystin-3

Protein Synonyms/Alias

Gene Name

NPHP3

Gene Synonyms/Alias

KIAA2000;

Created Date

05-JUL-2005

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
2	Canonical	******MGTASSLVS	[1]	N-Myristoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Wright KJ, Baye LM, Olivier-Mason A, Mukhopadhyay S, Sang L, Kwong M, Wang W, Pretorius PR, Sheffield VC, Sengupta P, Slusarski DC, Jackson PK. AnARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.Genes Dev. 2011 Nov 15;25(22):2347-60. doi: 10.1101/gad.173443.111.[PMID:22085962]

Functional Description

Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.

Sequence Annotation

Protein Length

1330 AA.

Protein Sequence
(Canonical)

MGTASSLVSP AGGEVIEDTY GAGGGEACEI PVEVKPKARL LRNSFRRGAG AAAGAGPGSL  60
PRGVGAGGLL GASFKSTGSS VPELEYAAAE YERLRKEYEI FRVSKNQELL SMGRREAKLD  120
TENKRLRAEL QALQKTYQKI LREKESALEA KYQAMERAAT FEHDRDKVKR QFKIFRETKE  180
NEIQDLLRAK RELESKLQRL QAQGIQVFDP GESDSDDNCT DVTAAGTQCE YWTGGALGSE  240
PSIGSMIQLQ QSFRGPEFAH SSIDVEGPFA NVNRDDWDIA VASLLQVTPL FSHSLWSNTV  300
RCYLIYTDET QPEMDLFLKD YSPKLKRMCE TMGYFFHAVY FPIDVENQYL TVRKWEIEKS  360
SLVILFIHLT LPSLLLEDCE EAFLKNPEGK PRLIFHRLED GKVSSDSVQQ LIDQVSNLNK  420
TSKAKIIDHS GDPAEGVYKT YICVEKIIKQ DILGFENTDL ETKDLGSEDS IPEEDDFGDV  480
LWDIHDEQEQ METFQQASNS AHELGFEKYY QRLNDLVAAP APIPPLLVSG GPGSGKSLLL  540
SKWIQLQQKN SPNTLILSHF VGRPMSTSSE SSLIIKRLTL KLMQHSWSVS ALTLDPAKLL  600
EEFPRWLEKL SARHQGSIII VIDSIDQVQQ VEKHMKWLID PLPVNVRVIV SVNVETCPPA  660
WRLWPTLHLD PLSPKDAKSI IIAECHSVDI KLSKEQEKKL ERHCRSATTC NALYVTLFGK  720
MIARAGRAGN LDKILHQCFQ CQDTLSLYRL VLHSIRESMA NDVDKELMKQ ILCLVNVSHN  780
GVSESELMEL YPEMSWTFLT SLIHSLYKMC LLTYGCGLLR FQHLQAWETV RLEYLEGPTV  840
TSSYRQKLIN YFTLQLSQDR VTWRSADELP WLFQQQGSKQ KLHDCLLNLF VSQNLYKRGH  900
FAELLSYWQF VGKDKSAMAT EYFDSLKQYE KNCEGEDNMS CLADLYETLG RFLKDLGLLS  960
QAIVPLQRSL EIRETALDPD HPRVAQSLHQ LASVYVQWKK FGNAEQLYKQ ALEISENAYG  1020
ADHPYTAREL EALATLYQKQ NKYEQAEHFR KKSFKIHQKA IKKKGNLYGF ALLRRRALQL  1080
EELTLGKDTP DNARTLNELG VLYYLQNNLE TADQFLKRSL EMRERVLGPD HPDCAQSLNN  1140
LAALCNEKKQ YDKAEELYER ALDIRRRALA PDHPSLAYTV KHLAILYKKM GKLDKAVPLY  1200
ELAVEIRQKS FGPKHPSVAT ALVNLAVLYS QMKKHVEALP LYERALKIYE DSLGRMHPRV  1260
GETLKNLAVL SYEGGDFEKA AELYKRAMEI KEAETSLLGG KAPSRHSSSG DTFSLKTAHS  1320
PNVFLQQGQR                                                         1330

FASTA
(Canonical)

>LipidDB-9606-01434|Q7Z494
MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRNSFRRGAGAAAGAGPGSL
PRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKEYEIFRVSKNQELLSMGRREAKLD
TENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKE
NEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWTGGALGSE
PSIGSMIQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDIAVASLLQVTPLFSHSLWSNTV
RCYLIYTDETQPEMDLFLKDYSPKLKRMCETMGYFFHAVYFPIDVENQYLTVRKWEIEKS
SLVILFIHLTLPSLLLEDCEEAFLKNPEGKPRLIFHRLEDGKVSSDSVQQLIDQVSNLNK
TSKAKIIDHSGDPAEGVYKTYICVEKIIKQDILGFENTDLETKDLGSEDSIPEEDDFGDV
LWDIHDEQEQMETFQQASNSAHELGFEKYYQRLNDLVAAPAPIPPLLVSGGPGSGKSLLL
SKWIQLQQKNSPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHSWSVSALTLDPAKLL
EEFPRWLEKLSARHQGSIIIVIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPPA
WRLWPTLHLDPLSPKDAKSIIIAECHSVDIKLSKEQEKKLERHCRSATTCNALYVTLFGK
MIARAGRAGNLDKILHQCFQCQDTLSLYRLVLHSIRESMANDVDKELMKQILCLVNVSHN
GVSESELMELYPEMSWTFLTSLIHSLYKMCLLTYGCGLLRFQHLQAWETVRLEYLEGPTV
TSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGH
FAELLSYWQFVGKDKSAMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLS
QAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYG
ADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQL
EELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNN
LAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY
ELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRV
GETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHS
PNVFLQQGQR

Gene Ontology

GO:0005929; C:cilium; IDA:UniProtKB
GO:0072372; C:primary cilium; IDA:UniProtKB
GO:0003283; P:atrial septum development; IMP:BHF-UCL
GO:0060271; P:cilium morphogenesis; ISS:UniProtKB
GO:0060027; P:convergent extension involved in gastrulation; IGI:BHF-UCL
GO:0071908; P:determination of intestine left/right asymmetry; IMP:BHF-UCL
GO:0007368; P:determination of left/right symmetry; IMP:BHF-UCL
GO:0071910; P:determination of liver left/right asymmetry; IMP:BHF-UCL
GO:0035469; P:determination of pancreatic left/right asymmetry; IMP:BHF-UCL
GO:0071909; P:determination of stomach left/right asymmetry; IMP:BHF-UCL
GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IC:BHF-UCL
GO:0007163; P:establishment or maintenance of cell polarity; IEA:Ensembl
GO:0030198; P:extracellular matrix organization; IEA:Ensembl
GO:0001947; P:heart looping; IMP:BHF-UCL
GO:0001822; P:kidney development; IMP:BHF-UCL
GO:0060993; P:kidney morphogenesis; IMP:BHF-UCL
GO:0006629; P:lipid metabolic process; IEA:Ensembl
GO:0030324; P:lung development; IMP:BHF-UCL
GO:0048496; P:maintenance of organ identity; IMP:HGNC
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:UniProtKB
GO:0045494; P:photoreceptor cell maintenance; IMP:HGNC
GO:0030814; P:regulation of cAMP metabolic process; IEA:Ensembl
GO:2000167; P:regulation of planar cell polarity pathway involved in neural tube closure; IC:BHF-UCL
GO:2000095; P:regulation of Wnt signaling pathway, planar cell polarity pathway; ISS:UniProtKB
GO:0072189; P:ureter development; IMP:BHF-UCL
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR013026; TPR-contain_dom
InterPro; IPR011990; TPR-like_helical_dom
InterPro; IPR019734; TPR_repeat

Pfam

Pfam; PF13176; TPR_7;

SMART

SMART; SM00028; TPR;

PROSITE

PROSITE; PS50005; TPR;
PROSITE; PS50293; TPR_REGION;

PRINTS