LipidDB ID

LipidDB-9606-01433

Entry Name

UniProt Accession

P84085; P26437;

Theoretical PI

6.3

Molecular Weight

20529.66

Genbank Protein ID

AAA90927.1; AAC51299.1; AAM12598.1; AAP35750.1; AAH03043.1; AAH33104.1;

Genbank Nucleotide ID

M57567; U73002; AF493884; BT007087; BC003043; BC033104;

Protein Name

ADP-ribosylation factor 5

Protein Synonyms/Alias

Gene Name

ARF5

Gene Synonyms/Alias

Created Date

16-AUG-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Haun RS, Tsai SC, Adamik R, Moss J, Vaughan M. Effect of myristoylation onGTP-dependent binding of ADP-ribosylation factor to Golgi. J Biol Chem. 1993 Apr 5;268(10):7064-8.[PMID:8463239]

Functional Description

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Sequence Annotation

Nucleotide-binding: 24 31 GTP.
Nucleotide-binding: 67 71 GTP.
Nucleotide-binding: 126 129 GTP.

Protein Length

180 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:Ensembl
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; TAS:ProtInc
GO:0006184; P:GTP catabolic process; TAS:GOC
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR024156; Small_GTPase_ARF
InterPro; IPR006689; Small_GTPase_ARF/SAR

Pfam

Pfam; PF00025; Arf;

SMART

SMART; SM00177; ARF;

PROSITE

PROSITE; PS51417; ARF;

PRINTS

PRINTS; PR00328; SAR1GTPBP;