LipidDB ID

LipidDB-9606-01421

Entry Name

UniProt Accession

P17081; D6W5A6; Q0VGN1; Q52LS8; Q53SJ1; Q6NS39; Q6P146; Q7Z480;

Theoretical PI

5.94

Molecular Weight

22659.46

Genbank Protein ID

AAA36547.1; AAM21123.1; AAY14834.1; EAX00251.1; AAH56154.3; AAH65291.2; AAH70485.2; AAH93805.2; AAI01807.1;

Genbank Nucleotide ID

M31470; AF498976; AC018682; CH471053; BC056154; BC065291; BC070485; BC093805; BC101806;

Protein Name

Rho-related GTP-binding protein RhoQ

Protein Synonyms/Alias

Ras-like protein TC10; Ras-like protein family member 7A;

Gene Name

RHOQ

Gene Synonyms/Alias

ARHQ; RASL7A; TC10;

Created Date

01-AUG-1990

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Tamanoi F, Gau CL, Jiang C, Edamatsu H, Kato-Stankiewicz J. Proteinfarnesylation in mammalian cells: effects of farnesyltransferase inhibitors oncancer cells. Cell Mol Life Sci. 2001 Oct;58(11):1636-49. Review.[PMID:11706990]

Functional Description

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

Sequence Annotation

Nucleotide-binding: 16 23 GTP.
Nucleotide-binding: 63 67 GTP.
Nucleotide-binding: 121 124 GTP.
Motif: 38 46 Effector region.
Modified residue: 202 202 Cysteine methyl ester.

Protein Length

205 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005884; C:actin filament; IDA:BHF-UCL
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:BHF-UCL
GO:0032427; F:GBD domain binding; IPI:BHF-UCL
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IDA:BHF-UCL
GO:0005522; F:profilin binding; IPI:BHF-UCL
GO:0032869; P:cellular response to insulin stimulus; IMP:BHF-UCL
GO:0030866; P:cortical actin cytoskeleton organization; IMP:BHF-UCL
GO:0006184; P:GTP catabolic process; IDA:BHF-UCL
GO:0008286; P:insulin receptor signaling pathway; IMP:BHF-UCL
GO:0090005; P:negative regulation of establishment of protein localization to plasma membrane; IMP:BHF-UCL
GO:0051491; P:positive regulation of filopodium assembly; IDA:BHF-UCL
GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL
GO:0032956; P:regulation of actin cytoskeleton organization; IC:BHF-UCL
GO:0008360; P:regulation of cell shape; IEA:Ensembl
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome
GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00174; RHO;

PROSITE

PROSITE; PS51420; RHO;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;