Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01418
Entry Name
UniProt Accession
Theoretical PI
6.2
Molecular Weight
22006.36
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Rho-related GTP-binding protein RhoC
Protein Synonyms/Alias
Rho cDNA clone 9; h9;
Gene Name
RHOC
Gene Synonyms/Alias
ARH9; ARHC;
Created Date
01-AUG-1988
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
190
Canonical
KNKRRRGCPIL****
[1][2]
S-Geranylgeranylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Adamson P, Marshall CJ, Hall A, Tilbrook PA. Post-translational modifications of p21rho proteins. J Biol Chem. 1992 Oct 5;267(28):20033-8.[PMID:1400319]
[2] Khwaja A, Sharpe CC, Noor M, Hendry BM. The role of geranylgeranylatedproteins in human mesangial cell proliferation. Kidney Int. 2006Oct;70(7):1296-304. Epub 2006 Aug 23.[PMID:16929252]
Functional Description
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
Sequence Annotation
Nucleotide-binding: 12 19 GTP.
Nucleotide-binding: 59 63 GTP.
Nucleotide-binding: 117 120 GTP.
Motif: 34 42 Effector region.
Modified residue: 41 41 ADP-ribosylasparagine; by botulinumtoxin.
Modified residue: 190 190 Cysteine methyl ester.
Protein Length
193 AA.
Protein Sequence
(Canonical)
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT  60
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD  120
LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ  180
VRKNKRRRGC PIL                                                     193
FASTA
(Canonical)
>LipidDB-9606-01418|P08134
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD
LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ
VRKNKRRRGCPIL
Gene Ontology
GO:0032154; C:cleavage furrow; IDA:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005634; C:nucleus; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0004871; F:signal transducer activity; IMP:UniProtKB
GO:0043297; P:apical junction assembly; IDA:UniProtKB
GO:0007411; P:axon guidance; TAS:Reactome
GO:0000910; P:cytokinesis; IDA:UniProtKB
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome
GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00174; RHO;
PROSITE
PROSITE; PS51420; RHO;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;