Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01416
Entry Name
UniProt Accession
Theoretical PI
6.24
Molecular Weight
20681.54
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
GTPase RhebL1
Protein Synonyms/Alias
Ras homolog enriched in brain like-1 c; RhebL1c; Ras homolog enriched in brain-like protein 1; Rheb-like protein 1; Rheb2;
Gene Name
RHEBL1
Gene Synonyms/Alias
Created Date
18-MAR-2008
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
180
Canonical
SYGQERRCHLM****
[1]
S-Farnesylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Basso AD, Mirza A, Liu G, Long BJ, Bishop WR, Kirschmeier P. The farnesyltransferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation andmTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumoractivity. J Biol Chem. 2005 Sep 2;280(35):31101-8. Epub 2005 Jul 8.[PMID:16006564]
Functional Description
Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
Sequence Annotation
Nucleotide-binding: 13 20 GTP.
Nucleotide-binding: 60 64 GTP.
Nucleotide-binding: 119 122 GTP.
Motif: 35 43 Effector region.
Modified residue: 180 180 Cysteine methyl ester.
Protein Length
183 AA.
Protein Sequence
(Canonical)
MPLVRYRKVV ILGYRCVGKT SLAHQFVEGE FSEGYDPTVE NTYSKIVTLG KDEFHLHLVD  60
TAGQDEYSIL PYSFIIGVHG YVLVYSVTSL HSFQVIESLY QKLHEGHGKT RVPVVLVGNK  120
ADLSPEREVQ AVEGKKLAES WGATFMESSA RENQLTQGIF TKVIQEIARV ENSYGQERRC  180
HLM                                                                183
FASTA
(Canonical)
>LipidDB-9606-01416|Q8TAI7
MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD
TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK
ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRC
HLM
Gene Ontology
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0031929; P:TOR signaling; IMP:UniProtKB
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00173; RAS;
PROSITE
PROSITE; PS51421; RAS;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;