| Tag |
Content |
LipidDB ID |
LipidDB-9606-01414 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.54 |
Molecular Weight |
67209.02 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Interferon-induced guanylate-binding protein 2 |
Protein Synonyms/Alias |
GTP-binding protein 2; GBP-2; HuGBP-2; Guanine nucleotide-binding protein 2; |
Gene Name |
GBP2 |
Gene Synonyms/Alias |
|
Created Date |
01-OCT-1993 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
588 | Canonical | SKSLEPICNIL**** | [1] | S-Geranylgeranylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Britzen-Laurent N, Bauer M, Berton V, Fischer N, Syguda A, Reipschläger S,Naschberger E, Herrmann C, Stürzl M. Intracellular trafficking ofguanylate-binding proteins is regulated by heterodimerization in a hierarchicalmanner. PLoS One. 2010 Dec 7;5(12):e14246. doi: 10.1371/journal.pone.0014246.[ PMID:21151871]
|
Functional Description |
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). |
Sequence Annotation |
Domain: 35 276 GB1/RHD3-type G.
Nucleotide-binding: 45 52 GTP.
Nucleotide-binding: 67 69 GTP.
Nucleotide-binding: 97 101 GTP.
Region: 1 309 GTPase domain (Globular).
Modified residue: 588 588 Cysteine methyl ester.
|
Protein Length |
591 AA. |
Protein Sequence
(Canonical) |
MAPEINLPGP MSLIDNTKGQ LVVNPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG 60
KKNGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDIEKGDNE NDSWIFALAI 120
LLSSTFVYNS MGTINQQAMD QLHYVTELTD RIKANSSPGN NSVDDSADFV SFFPAFVWTL 180
RDFTLELEVD GEPITADDYL ELSLKLRKGT DKKSKSFNDP RLCIRKFFPK RKCFVFDWPA 240
PKKYLAHLEQ LKEEELNPDF IEQVAEFCSY ILSHSNVKTL SGGIPVNGPR LESLVLTYVN 300
AISSGDLPCM ENAVLALAQI ENSAAVEKAI AHYEQQMGQK VQLPTETLQE LLDLHRDSER 360
EAIEVFMKNS FKDVDQMFQR KLGAQLEARR DDFCKQNSKA SSDCCMALLQ DIFGPLEEDV 420
KQGTFSKPGG YRLFTQKLQE LKNKYYQVPR KGIQAKEVLK KYLESKEDVA DALLQTDQSL 480
SEKEKAIEVE RIKAESAEAA KKMLEEIQKK NEEMMEQKEK SYQEHVKQLT EKMERDRAQL 540
MAEQEKTLAL KLQEQERLLK EGFENESKRL QKDIWDIQMR SKSLEPICNI L 591
|
FASTA
(Canonical) |
>LipidDB-9606-01414|P32456
MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI
LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL
RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA
PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVN
AISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSER
EAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV
KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSL
SEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQL
MAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL
|
Gene Ontology |
|
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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