| Tag |
Content |
LipidDB ID |
LipidDB-9606-01409 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
9.08 |
Molecular Weight |
52317.58 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Protein-cysteine N-palmitoyltransferase porcupine |
Protein Synonyms/Alias |
2.3.1.-; Protein MG61; |
Gene Name |
PORCN |
Gene Synonyms/Alias |
MG61; PORC; PPN; |
Created Date |
25-OCT-2005 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
187 | Canonical | VQGRPLSCRWLQKVA | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Gao X, Hannoush RN. Single-cell imaging of Wnt palmitoylation by theacyltransferase porcupine. Nat Chem Biol. 2014 Jan;10(1):61-8. doi:10.1038/nchembio.1392. Epub 2013 Nov 24.[ PMID:24292069]
|
Functional Description |
protein-cysteine N-palmitoyltransferase that modulates the processing of Wnt proteins by mediating serine palmitoylation of Wnt family members. |
Sequence Annotation |
Topological domain: 1 17 Cytoplasmic.
Transmembrane: 18 38 Helical.
Topological domain: 39 66 Extracellular.
Transmembrane: 67 87 Helical.
Topological domain: 88 95 Cytoplasmic.
Transmembrane: 96 116 Helical.
Topological domain: 117 152 Extracellular.
Transmembrane: 153 173 Helical.
Topological domain: 174 198 Cytoplasmic.
Transmembrane: 199 219 Helical.
Topological domain: 220 252 Extracellular.
Transmembrane: 253 273 Helical.
Topological domain: 274 337 Cytoplasmic.
Transmembrane: 338 358 Helical.
Topological domain: 359 396 Extracellular.
Transmembrane: 397 417 Helical.
Topological domain: 418 461 Cytoplasmic.
Active site: 341 341
|
Protein Length |
461 AA. |
Protein Sequence
(Canonical) |
MATFSRQEFF QQLLQGCLLP TAQQGLDQIW LLLAICLACR LLWRLGLPSY LKHASTVAGG 60
FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS VTILIYLLMG EMHMVDTVTW 120
HKMRGAQMIV AMKAVSLGFD LDRGEVGTVP SPVEFMGYLY FVGTIVFGPW ISFHSYLQAV 180
QGRPLSCRWL QKVARSLALA LLCLVLSTCV GPYLFPYFIP LNGDRLLRNK KRKARGTMVR 240
WLRAYESAVS FHFSNYFVGF LSEATATLAG AGFTEEKDHL EWDLTVSKPL NVELPRSMVE 300
VVTSWNLPMS YWLNNYVFKN ALRLGTFSAV LVTYAASALL HGFSFHLAAV LLSLAFITYV 360
EHVLRKRLAR ILSACVLSKR CPPDCSHQHR LGLGVRALNL LFGALAIFHL AYLGSLFDVD 420
VDDTTEEQGY GMAYTVHKWS ELSWASHWVT FGCWIFYRLI G 461
|
FASTA
(Canonical) |
>LipidDB-9606-01409|Q9H237
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
|
Gene Ontology |
GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; IEA:Ensembl GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:Ensembl GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW GO:0009100; P:glycoprotein metabolic process; IEA:Ensembl GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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