Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01406
Entry Name
UniProt Accession
Theoretical PI
7.79
Molecular Weight
101506.03
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Glutamate receptor 1
Protein Synonyms/Alias
GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1;
Gene Name
GRIA1
Gene Synonyms/Alias
GLUH1; GLUR1;
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
603
Canonical
GAFMQQGCDISPRSL
[1]
S-Palmitoylation
829
Canonical
LVALIEFCYKSRSES
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Hayashi T, Rumbaugh G, Huganir RL. Differential regulation of AMPA receptorsubunit trafficking by palmitoylation of two distinct sites. Neuron. 2005 Sep1;47(5):709-23.[PMID:16129400]
Functional Description
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Sequence Annotation
Topological domain: 19 536 Extracellular.
Transmembrane: 537 557 Helical.
Topological domain: 558 584 Cytoplasmic.
Topological domain: 604 609 Cytoplasmic.
Transmembrane: 610 630 Helical.
Topological domain: 631 805 Extracellular.
Transmembrane: 806 826 Helical; Name=M4.
Topological domain: 827 906 Cytoplasmic.
Region: 492 494 Glutamate binding.
Region: 668 669 Glutamate binding.
Motif: 903 906 PDZ-binding.
Binding site: 464 464 Glutamate.
Binding site: 499 499 Glutamate.
Binding site: 719 719 Glutamate.
Modified residue: 645 645 Phosphoserine.
Modified residue: 710 710 Phosphoserine.
Modified residue: 849 849 Phosphoserine.
Modified residue: 863 863 Phosphoserine.
Protein Length
906 AA.
Protein Sequence
(Canonical)
MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID  60
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ  120
FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT  180
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL  240
NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM  300
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR  360
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV  420
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE  480
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW  540
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ  600
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA  660
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES  720
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW  780
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK  840
GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP  900
LGATGL                                                             906
FASTA
(Canonical)
>LipidDB-9606-01406|P42261
MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKW
WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMP
LGATGL
Gene Ontology
GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; ISS:UniProtKB
GO:0044308; C:axonal spine; IEA:Ensembl
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0009986; C:cell surface; ISS:BHF-UCL
GO:0030425; C:dendrite; ISS:UniProtKB
GO:0032590; C:dendrite membrane; IEA:Ensembl
GO:0043197; C:dendritic spine; ISS:UniProtKB
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0044309; C:neuron spine; ISS:BHF-UCL
GO:0043025; C:neuronal cell body; ISS:BHF-UCL
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0014069; C:postsynaptic density; ISS:UniProtKB
GO:0045211; C:postsynaptic membrane; IBA:RefGenome
GO:0008021; C:synaptic vesicle; IEA:Ensembl
GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:UniProtKB
GO:0005234; F:extracellular-glutamate-gated ion channel activity; IBA:RefGenome
GO:0008066; F:glutamate receptor activity; TAS:ProtInc
GO:0030165; F:PDZ domain binding; ISS:BHF-UCL
GO:0034220; P:ion transmembrane transport; IBA:GOC
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IDA:GOC
GO:0007616; P:long-term memory; IEA:Ensembl
GO:0031623; P:receptor internalization; IEA:Ensembl
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0007268; P:synaptic transmission; TAS:Reactome
GO:0035249; P:synaptic transmission, glutamatergic; IBA:RefGenome
Interpro
InterPro; IPR001828; ANF_lig-bd_rcpt
InterPro; IPR019594; Glu_rcpt_Glu/Gly-bd
InterPro; IPR001320; Iontro_glu_rcpt
InterPro; IPR001508; NMDA_rcpt
InterPro; IPR028082; Peripla_BP_I
Pfam
Pfam; PF01094; ANF_receptor;
Pfam; PF00060; Lig_chan;
Pfam; PF10613; Lig_chan-Glu_bd;
SMART
SMART; SM00918; Lig_chan-Glu_bd;
SMART; SM00079; PBPe;
PROSITE
PRINTS
PRINTS; PR00177; NMDARECEPTOR;