LipidDB ID

LipidDB-9606-01405

Entry Name

UniProt Accession

P51153; A8K6B5; D3DV67; Q5U0A6; Q6GPG6; Q96GU4;

Theoretical PI

9.27

Molecular Weight

22774.12

Genbank Protein ID

CAA53266.1; AAS00485.1; AAM21096.1; BAF84269.1; AAV38506.1; AAV38507.1; CAI14031.1; EAW53249.1; EAW53250.1; AAH00799.1; AAH09227.2; AAH73168.2;

Genbank Nucleotide ID

X75593; AY423722; AF498948; AK291580; BT019700; BT019701; AL358472; CH471121; CH471121; BC000799; BC009227; BC073168;

Protein Name

Ras-related protein Rab-13

Protein Synonyms/Alias

Cell growth-inhibiting gene 4 protein;

Gene Name

RAB13

Gene Synonyms/Alias

GIG4;

Created Date

01-OCT-1996

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Joberty G, Tavitian A, Zahraoui A. Isoprenylation of Rab proteins possessing aC-terminal CaaX motif. FEBS Lett. 1993 Sep 20;330(3):323-8.[PMID:8375503]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.

Sequence Annotation

Nucleotide-binding: 15 22 GTP.
Nucleotide-binding: 63 67 GTP.
Nucleotide-binding: 121 124 GTP.
Motif: 37 45 Effector region.
Modified residue: 178 178 Phosphoserine.
Modified residue: 200 200 Cysteine methyl ester.

Protein Length

203 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:HPA
GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB
GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome
GO:0030139; C:endocytic vesicle; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0032593; C:insulin-responsive compartment; ISS:UniProtKB
GO:0030027; C:lamellipodium; ISS:UniProtKB
GO:0016328; C:lateral plasma membrane; IDA:UniProtKB
GO:0043005; C:neuron projection; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0055037; C:recycling endosome; IDA:UniProtKB
GO:0005923; C:tight junction; IDA:UniProtKB
GO:0005802; C:trans-Golgi network; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; EXP:Reactome
GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB
GO:0030866; P:cortical actin cytoskeleton organization; ISS:UniProtKB
GO:0032456; P:endocytic recycling; IMP:UniProtKB
GO:0016197; P:endosomal transport; IMP:UniProtKB
GO:0035767; P:endothelial cell chemotaxis; ISS:UniProtKB
GO:0090002; P:establishment of protein localization to plasma membrane; IMP:UniProtKB
GO:0097368; P:establishment of Sertoli cell barrier; ISS:UniProtKB
GO:0006184; P:GTP catabolic process; EXP:GOC
GO:0061024; P:membrane organization; TAS:Reactome
GO:0031175; P:neuron projection development; IMP:UniProtKB
GO:0010737; P:protein kinase A signaling; IMP:UniProtKB
GO:1902463; P:protein localization to cell leading edge; IEA:Ensembl
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0070830; P:tight junction assembly; IMP:UniProtKB
GO:0044795; P:trans-Golgi network to recycling endosome transport; ISS:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;