Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01402
Entry Name
UniProt Accession
Theoretical PI
5.85
Molecular Weight
77478.07
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Dixin
Protein Synonyms/Alias
Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain-containing protein 1;
Gene Name
DIXDC1
Gene Synonyms/Alias
CCD1; KIAA1735;
Created Date
15-MAY-2007
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Isoform 2
******MGGTQVKCL
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Suzuki T, Moriya K, Nagatoshi K, Ota Y, Ezure T, Ando E, Tsunasawa S, UtsumiT. Strategy for comprehensive identification of human N-myristoylated proteinsusing an insect cell-free protein synthesis system. Proteomics. 2010May;10(9):1780-93. doi: 10.1002/pmic.200900783.[PMID:20213681]
Functional Description
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
Sequence Annotation
Domain: 20 127 CH.
Domain: 600 680 DIX.
Region: 127 300 Actin-binding.
Protein Length
683 AA.
Protein Sequence
(Isoform 2)
MGGTQVKCLT SPSPIHSAKS ESIITQSEEK ADFVIIPAEG IENRTEGTDS PLSRDWRPGS  60
PGTYLETSWE EQLLEQQEYL EKEMEEAKKM ISGLQALLLN GSLPEDEQER PLALCEPGVN  120
PEEQLIIIQS RLDQSMEENQ DLKKELLKCK QEARNLQGIK DALQQRLTQQ DTSVLQLKQE  180
LLRANMDKDE LHNQNVDLQR KLDERNRLLG EYKKELGQKD RLLQQHQAKL EEALRKLSDV  240
SYHQVDLERE LEHKDVLLAH CMKREADEAT NYNSHNSQSN GFLLPTAGKG ATSVSNRGTS  300
DLQLVRDALR SLRNSFSGHD PQHHTIDSLE QGISSLMERL HVMETQKKQE RKVRVKSPRT  360
QVGSEYRESW PPNSKLPHSQ SSPTVSSTCT KVLYFTDRSL TPFMVNIPKR LEEVTLKDFK  420
AAIDREGNHR YHFKALDPEF GTVKEEIFHD DDAIPGWEGK IVAWVEEDHG EN          472
FASTA
(Isoform 2)
>LipidDB-9606-01402|Q155Q3-2
MGGTQVKCLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGS
PGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVN
PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE
LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDV
SYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTS
DLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRT
QVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFK
AAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN
Gene Ontology
GO:0043679; C:axon terminus; IBA:RefGenome
GO:0005938; C:cell cortex; IBA:RefGenome
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0043025; C:neuronal cell body; IBA:RefGenome
GO:0043234; C:protein complex; IEA:Ensembl
GO:0043015; F:gamma-tubulin binding; IDA:UniProtKB
GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IBA:RefGenome
GO:0043010; P:camera-type eye development; IBA:RefGenome
GO:0007049; P:cell cycle; IEA:Ensembl
GO:0021695; P:cerebellar cortex development; IBA:RefGenome
GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Ensembl
GO:0030900; P:forebrain development; IBA:RefGenome
GO:0021869; P:forebrain ventricular zone progenitor cell division; IEA:Ensembl
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl
GO:0050772; P:positive regulation of axonogenesis; IBA:RefGenome
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:UniProtKB
GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl
GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl
GO:0046328; P:regulation of JNK cascade; IBA:RefGenome
GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW
Interpro
InterPro; IPR001715; CH-domain
InterPro; IPR001158; DIX
InterPro; IPR015506; Dsh/Dvl-rel
InterPro; IPR029071; Ubiquitin-rel_dom
Pfam
Pfam; PF00307; CH;
Pfam; PF00778; DIX;
SMART
SMART; SM00033; CH;
PROSITE
PROSITE; PS50021; CH;
PROSITE; PS50841; DIX;
PRINTS