Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01395
Entry Name
UniProt Accession
Theoretical PI
8.72
Molecular Weight
101156.69
Genbank Protein ID
AAA67923.1; AAA67922.1; CAA57567.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF61847.1; AAF97857.1; AAF97857.1; AAF97857.1; AAF97857.1; AAF97858.1; AAF97858.1; AAF97858.1; AAF97858.1; AAF97858.1; AAF97858.1; AAF97858.1; AAF97858.1; AAF97858.1; AAF97858.1; AAF97859.1; AAF97859.1; AAF97859.1; AAF97859.1; AAF97859.1; AAF97859.1; AAF97859.1; AAF97859.1; AAF97859.1; AAF97859.1; CAI95643.1; CAI95643.1; CAI95643.1; CAI95643.1; CAI95643.1; CAI95644.1; CAI95644.1; CAI95644.1; CAI95644.1; CAI95644.1; CAI95164.1; CAI95164.1; CAI95164.1; CAI95164.1; CAI95164.1; CAI95165.1; CAI95165.1; CAI95165.1; CAI95165.1; CAI95165.1; CAI95709.1; CAI95709.1; CAI95709.1; CAI95709.1; CAI95709.1; CAI95710.1; CAI95710.1; CAI95710.1; CAI95710.1; CAI95710.1; CAI95664.1; CAI95664.1; CAI95664.1; CAI95664.1; CAI95664.1; CAI95665.1; CAI95665.1; CAI95665.1; CAI95665.1; CAI95665.1; CAI95683.1; CAI95683.1; CAI95683.1; CAI95683.1; CAI95683.1; CAI95684.1; CAI95684.1; CAI95684.1; CAI95684.1; CAI95684.1; EAX11865.1; EAX11867.1;
Genbank Nucleotide ID
U10302; U10301; X82068; AF159277; AF159262; AF159263; AF159264; AF159265; AF159266; AF159267; AF159268; AF159269; AF159270; AF159271; AF159272; AF159273; AF159274; AF159275; AF166365; AF166362; AF166363; AF166364; AF167332; AF166366; AF166367; AF166368; AF166369; AF166370; AF166371; AF166372; AF166373; AF166375; AF167332; AF166366; AF166367; AF166368; AF166369; AF166370; AF166371; AF166372; AF166373; AF166374; AL356213; AL035426; AL590139; Z83848; Z82899; AL356213; AL035426; AL590139; Z83848; Z82899; AL590139; AL035426; AL356213; Z83848; Z82899; AL590139; AL035426; AL356213; Z83848; Z82899; Z83848; AL590139; AL356213; AL035426; Z82899; Z83848; AL590139; AL356213; AL035426; Z82899; Z82899; Z83848; AL590139; AL356213; AL035426; Z82899; Z83848; AL590139; AL356213; AL035426; AL035426; Z83848; Z82899; AL590139; AL356213; AL035426; Z83848; Z82899; AL590139; AL356213; CH471107; CH471107;
Protein Name
Glutamate receptor 3
Protein Synonyms/Alias
GluR-3; AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3;
Gene Name
GRIA3
Gene Synonyms/Alias
GLUR3; GLURC;
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
621
Canonical
GAFMQQGCDISPRSL
[1]
S-Palmitoylation
847
Canonical
MVALIEFCYKSRAES
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Hayashi T, Rumbaugh G, Huganir RL. Differential regulation of AMPA receptorsubunit trafficking by palmitoylation of two distinct sites. Neuron. 2005 Sep1;47(5):709-23.[PMID:16129400]
Functional Description
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Sequence Annotation
Topological domain: 29 552 Extracellular.
Transmembrane: 553 573 Helical.
Topological domain: 574 602 Cytoplasmic.
Topological domain: 622 627 Cytoplasmic.
Transmembrane: 628 648 Helical.
Topological domain: 649 823 Extracellular.
Transmembrane: 824 844 Helical; Name=M4.
Topological domain: 845 894 Cytoplasmic.
Region: 508 510 Glutamate binding.
Region: 686 687 Glutamate binding.
Binding site: 480 480 Glutamate.
Binding site: 515 515 Glutamate.
Binding site: 737 737 Glutamate.
Modified residue: 877 877 Phosphotyrosine.
Modified residue: 887 887 Phosphotyrosine.
Protein Length
894 AA.
Protein Sequence
(Canonical)
MARQKKMGQS VLRAVFFLVL GLLGHSHGGF PNTISIGGLF MRNTVQEHSA FRFAVQLYNT  60
NQNTTEKPFH LNYHVDHLDS SNSFSVTNAF CSQFSRGVYA IFGFYDQMSM NTLTSFCGAL  120
HTSFVTPSFP TDADVQFVIQ MRPALKGAIL SLLGHYKWEK FVYLYDTERG FSILQAIMEA  180
AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS  240
RGYHYMLANL GFTDILLERV MHGGANITGF QIVNNENPMV QQFIQRWVRL DEREFPEAKN  300
APLKYTSALT HDAILVIAEA FRYLRRQRVD VSRRGSAGDC LANPAVPWSQ GIDIERALKM  360
VQVQGMTGNI QFDTYGRRTN YTIDVYEMKV SGSRKAGYWN EYERFVPFSD QQISNDSASS  420
ENRTIVVTTI LESPYVMYKK NHEQLEGNER YEGYCVDLAY EIAKHVRIKY KLSIVGDGKY  480
GARDPETKIW NGMVGELVYG RADIAVAPLT ITLVREEVID FSKPFMSLGI SIMIKKPQKS  540
KPGVFSFLDP LAYEIWMCIV FAYIGVSVVL FLVSRFSPYE WHLEDNNEEP RDPQSPPDPP  600
NEFGIFNSLW FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER  660
MVSPIESAED LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWSYMKSAE PSVFTKTTAD  720
GVARVRKSKG KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSALRNAVNL  780
AVLKLNEQGL LDKLKNKWWY DKGECGSGGG DSKDKTSALS LSNVAGVFYI LVGGLGLAMM  840
VALIEFCYKS RAESKRMKLT KNTQNFKPAP ATNTQNYATY REGYNVYGTE SVKI        894
FASTA
(Canonical)
>LipidDB-9606-01395|P42263
MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT
NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL
HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA
AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS
RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN
APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM
VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS
ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY
GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS
KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP
NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER
MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD
GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNL
AVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMM
VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
Gene Ontology
GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; ISS:UniProtKB
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0030425; C:dendrite; IBA:RefGenome
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0045211; C:postsynaptic membrane; IBA:RefGenome
GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:UniProtKB
GO:0005234; F:extracellular-glutamate-gated ion channel activity; IBA:RefGenome
GO:0007215; P:glutamate receptor signaling pathway; TAS:ProtInc
GO:0034220; P:ion transmembrane transport; IBA:GOC
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IDA:GOC
GO:0007268; P:synaptic transmission; TAS:Reactome
GO:0035249; P:synaptic transmission, glutamatergic; IBA:RefGenome
GO:0006810; P:transport; TAS:ProtInc
Interpro
InterPro; IPR001828; ANF_lig-bd_rcpt
InterPro; IPR019594; Glu_rcpt_Glu/Gly-bd
InterPro; IPR001320; Iontro_glu_rcpt
InterPro; IPR001508; NMDA_rcpt
InterPro; IPR028082; Peripla_BP_I
Pfam
Pfam; PF01094; ANF_receptor;
Pfam; PF00060; Lig_chan;
Pfam; PF10613; Lig_chan-Glu_bd;
SMART
SMART; SM00918; Lig_chan-Glu_bd;
SMART; SM00079; PBPe;
PROSITE
PRINTS
PRINTS; PR00177; NMDARECEPTOR;