Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01394
Entry Name
UniProt Accession
Theoretical PI
8.9
Molecular Weight
40956.04
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Prostacyclin receptor
Protein Synonyms/Alias
Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor;
Gene Name
PTGIR
Gene Synonyms/Alias
PRIPR;
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
308
Canonical
QRLKLWVCCLCLGPA
[1]
S-Palmitoylation
311
Canonical
KLWVCCLCLGPAHGD
[1]
S-Palmitoylation
383
Canonical
KAEASVACSLC****
[2]
S-Farnesylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Miggin SM, Lawler OA, Kinsella BT. Palmitoylation of the human prostacyclinreceptor. Functional implications of palmitoylation and isoprenylation. J BiolChem. 2003 Feb 28;278(9):6947-58. Epub 2002 Dec 17.[PMID:12488443]
[2] Miggin SM, Lawler OA, Kinsella BT. Investigation of a functional requirementfor isoprenylation by the human prostacyclin receptor. Eur J Biochem. 2002Mar;269(6):1714-25.[PMID:11895442]
Functional Description
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Sequence Annotation
Topological domain: 1 16 Extracellular.
Transmembrane: 17 38 Helical; Name=1.
Topological domain: 39 51 Cytoplasmic.
Transmembrane: 52 76 Helical; Name=2.
Topological domain: 77 94 Extracellular.
Transmembrane: 95 115 Helical; Name=3.
Topological domain: 116 134 Cytoplasmic.
Transmembrane: 135 158 Helical; Name=4.
Topological domain: 159 181 Extracellular.
Transmembrane: 182 208 Helical; Name=5.
Topological domain: 209 235 Cytoplasmic.
Transmembrane: 236 260 Helical; Name=6.
Topological domain: 261 274 Extracellular.
Transmembrane: 275 295 Helical; Name=7.
Topological domain: 296 386 Cytoplasmic.
Functional site: 309 309 Not S-palmitoylated.
Modified residue: 383 383 Cysteine methyl ester.
Protein Length
386 AA.
Protein Sequence
(Canonical)
MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA VLVTGLAATD  60
LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT FFGLASMLIL FAMAVERCLA  120
LSHPYLYAQL DGPRCARLAL PAIYAFCVLF CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG  180
GAAFSLAYAG LVALLVAAIF LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL  240
LALMTVVMAV CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF  300
QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS AWGEGQVEPL  360
PPTQQSSGSA VGTSSKAEAS VACSLC                                       386
MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA VLVTGLAATD  60
LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT FFGLASMLIL FAMAVERCLA  120
LSHPYLYAQL DGPRCARLAL PAIYAFCVLF CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG  180
GAAFSLAYAG LVALLVAAIF LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL  240
LALMTVVMAV CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF  300
QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS AWGEGQVEPL  360
PPTQQSSGSA VGTSSKAEAS VACSLC                                       386
FASTA
(Canonical)
>LipidDB-9606-01394|P43119
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
Gene Ontology
GO:0005829; C:cytosol; IDA:BHF-UCL
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; IDA:BHF-UCL
GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW
GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IMP:BHF-UCL
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007267; P:cell-cell signaling; TAS:ProtInc
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; ISS:BHF-UCL
GO:0048662; P:negative regulation of smooth muscle cell proliferation; IDA:BHF-UCL
GO:0030819; P:positive regulation of cAMP biosynthetic process; IMP:BHF-UCL
GO:0043950; P:positive regulation of cAMP-mediated signaling; IMP:BHF-UCL
GO:0043547; P:positive regulation of GTPase activity; TAS:GOC
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl
Interpro
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR008365; Prostanoid_rcpt
InterPro; IPR000370; Prostglndn_IP_rcpt
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR01788; PROSTANOIDR;
PRINTS; PR00856; PRSTNOIDIPR;