LipidDB-9606-01388

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-01388

Entry Name

GPC5C_HUMAN

UniProt Accession

Q9NQ84; B5BUN4; Q2NL85; Q9NZG5;

Theoretical PI

8.72

Molecular Weight

48193.22

Genbank Protein ID

CAC00633.1; AAF72870.1; AAP36103.1; BAG54752.1; BAC11595.1; BAG70284.1; EAW89163.1; AAH16860.2; AAI10849.1; AAI25081.1; AAI25082.1;

Genbank Nucleotide ID

AJ276102; AF207989; BT007435; AK131210; AK075397; AB451470; AC079325; CH471099; BC016860; BC110848; BC125080; BC125081;

Protein Name

G-protein coupled receptor family C group 5 member C

Protein Synonyms/Alias

Retinoic acid-induced gene 3 protein; RAIG-3;

Gene Name

GPRC5C

Gene Synonyms/Alias

RAIG3; PSEC0087;

Created Date

13-APR-2004

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
10	Canonical	IHKALVMCLGLPLFL	[1]	S-Palmitoylation
102	Canonical	LGTLGLFCLVFACVV	[1]	S-Palmitoylation
232	Canonical	LGAWPALCGRYKRWR	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Sequence Annotation

Topological domain: 24 50 Extracellular.
Transmembrane: 51 71 Helical; Name=1.
Topological domain: 72 85 Cytoplasmic.
Transmembrane: 86 106 Helical; Name=2.
Topological domain: 107 120 Extracellular.
Transmembrane: 121 141 Helical; Name=3.
Topological domain: 142 155 Cytoplasmic.
Transmembrane: 156 176 Helical; Name=4.
Topological domain: 177 208 Extracellular.
Transmembrane: 209 229 Helical; Name=5.
Topological domain: 230 241 Cytoplasmic.
Transmembrane: 242 262 Helical; Name=6.
Topological domain: 263 279 Extracellular.
Transmembrane: 280 300 Helical; Name=7.
Topological domain: 301 441 Cytoplasmic.

Protein Length

441 AA.

Protein Sequence
(Canonical)

MAIHKALVMC LGLPLFLFPG AWAQGHVPPG CSQGLNPLYY NLCDRSGAWG IVLEAVAGAG  60
IVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL FCLVFACVVK PDFSTCASRR  120
FLFGVLFAIC FSCLAAHVFA LNFLARKNHG PRGWVIFTVA LLLTLVEVII NTEWLIITLV  180
RGSGEGGPQG NSSAGWAVAS PCAIANMDFV MALIYVMLLL LGAFLGAWPA LCGRYKRWRK  240
HGVFVLLTTA TSVAIWVVWI VMYTYGNKQH NSPTWDDPTL AIALAANAWA FVLFYVIPEV  300
SQVTKSSPEQ SYQGDMYPTR GVGYETILKE QKGQSMFVEN KAFSMDEPVA AKRPVSPYSG  360
YNGQLLTSVY QPTEMALMHK VPSEGAYDII LPRATANSQV MGSANSTLRA EDMYSAQSHQ  420
AATPPKDGKN SQVFRNPYVW D                                            441

FASTA
(Canonical)

>LipidDB-9606-01388|Q9NQ84
MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAVAGAG
IVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRR
FLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLV
RGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCGRYKRWRK
HGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVLFYVIPEV
SQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQSMFVENKAFSMDEPVAAKRPVSPYSG
YNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAEDMYSAQSHQ
AATPPKDGKNSQVFRNPYVWD

Gene Ontology

GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0043235; C:receptor complex; IDA:MGI
GO:0031982; C:vesicle; IDA:UniProtKB
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc

Interpro

InterPro; IPR017978; GPCR_3_C

Pfam

Pfam; PF00003; 7tm_3;

SMART

PROSITE

PROSITE; PS50259; G_PROTEIN_RECEP_F3_4;

PRINTS