| Tag |
Content |
LipidDB ID |
LipidDB-9606-01372 |
Entry Name |
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UniProt Accession |
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Theoretical PI |
5.71 |
Molecular Weight |
54744.21 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Phosphatidylinositol 4-kinase type 2-beta |
Protein Synonyms/Alias |
2.7.1.67; Phosphatidylinositol 4-kinase type II-beta; PI4KII-BETA; |
Gene Name |
PI4K2B |
Gene Synonyms/Alias |
|
Created Date |
01-MAY-2007 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
170 | Canonical | TKYVHKVCCPCCFGR | [1] | S-Palmitoylation | 171 | Canonical | KYVHKVCCPCCFGRG | [1] | S-Palmitoylation | 173 | Canonical | VHKVCCPCCFGRGCL | [1] | S-Palmitoylation | 174 | Canonical | HKVCCPCCFGRGCLI | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. |
Sequence Annotation |
Domain: 129 436 PI3K/PI4K.
Modified residue: 12 12 Phosphoserine.
Modified residue: 17 17 Phosphoserine.
|
Protein Length |
481 AA. |
Protein Sequence
(Canonical) |
MEDPSEPDRL ASADGGSPEE EEDGEREPLL PRIAWAHPRR GAPGSAVRLL DAAGEEGEAG 60
DEELPLPPGD VGVSRSSSAE LDRSRPAVSV TIGTSEMNAF LDDPEFADIM LRAEQAIEVG 120
IFPERISQGS SGSYFVKDPK RKIIGVFKPK SEEPYGQLNP KWTKYVHKVC CPCCFGRGCL 180
IPNQGYLSEA GAYLVDNKLH LSIVPKTKVV WLVSETFNYN AIDRAKSRGK KYALEKVPKV 240
GRKFHRIGLP PKIGSFQLFV EGYKEAEYWL RKFEADPLPE NIRKQFQSQF ERLVILDYII 300
RNTDRGNDNW LVRYEKQKCE KEIDHKESKW IDDEEFLIKI AAIDNGLAFP FKHPDEWRAY 360
PFHWAWLPQA KVPFSEEIRN LILPYISDMN FVQDLCEDLY ELFKTDKGFD KATFESQMSV 420
MRGQILNLTQ ALRDGKSPFQ LVQIPCVIVE RSQGGSQGRI VHLSNSFTQT VNCRKPFFSS 480
W 481
|
FASTA
(Canonical) |
>LipidDB-9606-01372|Q8TCG2
MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAG
DEELPLPPGDVGVSRSSSAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVG
IFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCL
IPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKV
GRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYII
RNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAY
PFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSV
MRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSS
W
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Gene Ontology |
GO:0005737; C:cytoplasm; IDA:HPA GO:0005829; C:cytosol; TAS:Reactome GO:0016020; C:membrane; IDA:UniProtKB GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:UniProtKB-EC GO:0005524; F:ATP binding; IEA:UniProtKB-KW GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome GO:0006644; P:phospholipid metabolic process; TAS:Reactome GO:0044281; P:small molecule metabolic process; TAS:Reactome |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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