LipidDB ID

LipidDB-9606-01356

Entry Name

UniProt Accession

Q86UE4; Q05DH2; Q52QU9; Q6PK07; Q8TCX3;

Theoretical PI

9.33

Molecular Weight

63836.99

Genbank Protein ID

AAP30791.1; AAL92861.1; AAO65771.1; AAX84832.1; AAH09324.1; AAH14977.1; AAH45642.1;

Genbank Nucleotide ID

AF501310; AY082966; AF411226; AY974040; BC009324; BC014977; BC045642; AK000745;

Protein Name

Protein LYRIC

Protein Synonyms/Alias

3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein;

Gene Name

MTDH

Gene Synonyms/Alias

AEG1; LYRIC;

Created Date

21-DEC-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Sequence Annotation

Topological domain: 1 48 Lumenal.
Transmembrane: 49 69 Helical.
Topological domain: 70 582 Cytoplasmic.
Region: 1 71 Activation of NF-kappa-B.
Region: 72 169 Interaction with BCCIP.
Region: 101 205 Interaction with RELA.
Region: 381 443 Lung-homing for mammary tumors.
Modified residue: 143 143 Phosphothreonine.
Modified residue: 264 264 N6-acetyllysine.
Modified residue: 298 298 Phosphoserine.
Modified residue: 306 306 Phosphoserine.
Modified residue: 308 308 Phosphoserine.
Modified residue: 311 311 Phosphoserine.
Modified residue: 344 344 Phosphoserine.
Modified residue: 369 369 Phosphoserine.
Modified residue: 415 415 Phosphoserine.
Modified residue: 426 426 Phosphoserine.
Modified residue: 458 458 Phosphothreonine.
Modified residue: 568 568 Phosphoserine.

Protein Length

582 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016324; C:apical plasma membrane; ISS:UniProtKB
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB
GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0046581; C:intercellular canaliculus; ISS:UniProtKB
GO:0016604; C:nuclear body; IDA:UniProtKB
GO:0005730; C:nucleolus; IDA:HPA
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB
GO:0005923; C:tight junction; ISS:UniProtKB
GO:0003725; F:double-stranded RNA binding; IDA:MGI
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB
GO:0003713; F:transcription coactivator activity; IMP:UniProtKB
GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IMP:UniProtKB
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB
GO:0045766; P:positive regulation of angiogenesis; IDA:UniProtKB
GO:0010508; P:positive regulation of autophagy; IDA:UniProtKB
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:UniProtKB
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB
GO:0051897; P:positive regulation of protein kinase B signaling; IDA:UniProtKB
GO:0070830; P:tight junction assembly; IEA:Ensembl

Interpro

Pfam

SMART

PROSITE

PRINTS