Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01323
Entry Name
UniProt Accession
Theoretical PI
5.08
Molecular Weight
71456.59
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Cytoplasmic dynein 1 intermediate chain 2
Protein Synonyms/Alias
Cytoplasmic dynein intermediate chain 2; Dynein intermediate chain 2, cytosolic; DH IC-2;
Gene Name
DYNC1I2
Gene Synonyms/Alias
DNCI2; DNCIC2;
Created Date
01-NOV-1997
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
107
Canonical
GSQDSGDGAVGSRTL
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Martin DD, Vilas GL, Prescher JA, Rajaiah G, Falck JR, Bertozzi CR, BerthiaumeLG. Rapid detection, discovery, and identification of post-translationallymyristoylated proteins during apoptosis using a bio-orthogonal azidomyristateanalog. FASEB J. 2008 Mar;22(3):797-806. Epub 2007 Oct 10.[PMID:17932026]
Functional Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Sequence Annotation
Modified residue: 2 2 N-acetylserine.
Modified residue: 90 90 Phosphoserine.
Modified residue: 97 97 Phosphoserine.
Modified residue: 101 101 Phosphoserine.
Modified residue: 104 104 Phosphoserine.
Protein Length
638 AA.
Protein Sequence
(Canonical)
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA  60
EALLQSMGLT PESPIVFSEY WVPPPMSPSS KSVSTPSEAG SQDSGDGAVG SRTLHWDTDP  120
SVLQLHSDSD LGRGPIKLGM AKITQVDFPP REIVTYTKET QTPVMAQPKE DEEEDDDVVA  180
PKPPIEPEEE KTLKKDEEND SKAPPHELTE EEKQQILHSE EFLSFFDHST RIVERALSEQ  240
INIFFDYSGR DLEDKEGEIQ AGAKLSLNRQ FFDERWSKHR VVSCLDWSSQ YPELLVASYN  300
NNEDAPHEPD GVALVWNMKY KKTTPEYVFH CQSAVMSATF AKFHPNLVVG GTYSGQIVLW  360
DNRSNKRTPV QRTPLSAAAH THPVYCVNVV GTQNAHNLIS ISTDGKICSW SLDMLSHPQD  420
SMELVHKQSK AVAVTSMSFP VGDVNNFVVG SEEGSVYTAC RHGSKAGISE MFEGHQGPIT  480
GIHCHAAVGA VDFSHLFVTS SFDWTVKLWT TKNNKPLYSF EDNADYVYDV MWSPTHPALF  540
ACVDGMGRLD LWNLNNDTEV PTASISVEGN PALNRVRWTH SGREIAVGDS EGQIVIYDVG  600
EQIAVPRNDE WARFGRTLAE INANRADAEE EAATRIPA                          638
FASTA
(Canonical)
>LipidDB-9606-01323|Q13409
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDP
SVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVA
PKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQ
INIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYN
NNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQD
SMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPIT
GIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPALF
ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG
EQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA
Gene Ontology
GO:0005813; C:centrosome; IDA:UniProtKB
GO:0005737; C:cytoplasm; NAS:UniProtKB
GO:0005868; C:cytoplasmic dynein complex; IEA:InterPro
GO:0005829; C:cytosol; TAS:Reactome
GO:0005874; C:microtubule; IDA:UniProtKB
GO:0031982; C:vesicle; IDA:UniProtKB
GO:0003777; F:microtubule motor activity; NAS:UniProtKB
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome
GO:0008152; P:metabolic process; NAS:GOC
GO:0007018; P:microtubule-based movement; NAS:UniProtKB
GO:0000278; P:mitotic cell cycle; TAS:Reactome
GO:0006810; P:transport; IEA:UniProtKB-KW
GO:0016032; P:viral process; IEA:UniProtKB-KW
Interpro
InterPro; IPR025956; Dynein_IC_1/2
InterPro; IPR015943; WD40/YVTN_repeat-like_dom
InterPro; IPR001680; WD40_repeat
InterPro; IPR017986; WD40_repeat_dom
Pfam
Pfam; PF11540; Dynein_IC2;
Pfam; PF00400; WD40;
SMART
SMART; SM00320; WD40;
PROSITE
PROSITE; PS50294; WD_REPEATS_REGION;
PRINTS