Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01319
Entry Name
UniProt Accession
Theoretical PI
4.95
Molecular Weight
23822.12
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Guanylyl cyclase-activating protein 3
Protein Synonyms/Alias
GCAP 3; Guanylate cyclase activator 1C;
Gene Name
GUCA1C
Gene Synonyms/Alias
GCAP3;
Created Date
30-MAY-2000
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGNGKSIAG
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Haeseleer F, Sokal I, Li N, Pettenati M, Rao N, Bronson D, Wechter R, Baehr W,Palczewski K. Molecular characterization of a third member of the guanylylcyclase-activating protein subfamily. J Biol Chem. 1999 Mar 5;274(10):6526-35.[PMID:10037746]
Functional Description
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Sequence Annotation
Domain: 15 50 EF-hand 1.
Domain: 52 87 EF-hand 2.
Domain: 88 123 EF-hand 3.
Domain: 130 165 EF-hand 4.
Modified residue: 3 3 Deamidated asparagine.
Protein Length
209 AA.
Protein Sequence
(Canonical)
MGNGKSIAGD QKAVPTQETH VWYRTFMMEY PSGLQTLHEF KTLLGLQGLN QKANKHIDQV  60
YNTFDTNKDG FVDFLEFIAA VNLIMQEKME QKLKWYFKLY DADGNGSIDK NELLDMFMAV  120
QALNGQQTLS PEEFINLVFH KIDINNDGEL TLEEFINGMA KDQDLLEIVY KSFDFSNVLR  180
VICNGKQPDM ETDSSKSPDK AGLGKVKMK                                    209
FASTA
(Canonical)
>LipidDB-9606-01319|O95843
MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQV
YNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAV
QALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLR
VICNGKQPDMETDSSKSPDKAGLGKVKMK
Gene Ontology
GO:0097381; C:photoreceptor disc membrane; TAS:Reactome
GO:0005509; F:calcium ion binding; IEA:InterPro
GO:0008048; F:calcium sensitive guanylate cyclase activator activity; TAS:ProtInc
GO:0007603; P:phototransduction, visible light; TAS:Reactome
GO:0031284; P:positive regulation of guanylate cyclase activity; TAS:GOC
GO:0022400; P:regulation of rhodopsin mediated signaling pathway; TAS:Reactome
GO:0016056; P:rhodopsin mediated signaling pathway; TAS:Reactome
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0007601; P:visual perception; TAS:ProtInc
Interpro
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
InterPro; IPR028846; Recoverin
Pfam
Pfam; PF00036; EF-hand_1;
Pfam; PF13405; EF-hand_6;
SMART
SMART; SM00054; EFh;
PROSITE
PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;
PRINTS