Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01318
Entry Name
UniProt Accession
Theoretical PI
9.69
Molecular Weight
12073.79
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Tumor suppressor candidate 2
Protein Synonyms/Alias
Fusion 1 protein; Fus-1 protein; PDGFA-associated protein 2;
Gene Name
TUSC2
Gene Synonyms/Alias
C3orf11; FUS1; LGCC; PDAP2;
Created Date
30-MAY-2000
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGASGSKAR
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Uno F, Sasaki J, Nishizaki M, Carboni G, Xu K, Atkinson EN, Kondo M, Minna JD,Roth JA, Ji L. Myristoylation of the fus1 protein is required for tumorsuppression in human lung cancer cells. Cancer Res. 2004 May 1;64(9):2969-76.[PMID:15126327]
Functional Description
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
Sequence Annotation
Modified residue: 50 50 Phosphoserine.
Protein Length
110 AA.
Protein Sequence
(Canonical)
MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS MFYDEDGDLA  60
HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH VDFPVILYEV             110
FASTA
(Canonical)
>LipidDB-9606-01318|O75896
MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGSMFYDEDGDLA
HEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVDFPVILYEV
Gene Ontology
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0048469; P:cell maturation; IEA:Ensembl
GO:0008283; P:cell proliferation; TAS:ProtInc
GO:0007267; P:cell-cell signaling; TAS:ProtInc
GO:0071609; P:chemokine (C-C motif) ligand 5 production; IEA:Ensembl
GO:0006954; P:inflammatory response; IEA:Ensembl
GO:0032618; P:interleukin-15 production; IEA:Ensembl
GO:0001779; P:natural killer cell differentiation; IEA:Ensembl
GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl
GO:0070945; P:neutrophil mediated killing of gram-negative bacterium; IEA:Ensembl
GO:0006909; P:phagocytosis; IEA:Ensembl
GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl
GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:Ensembl
GO:0052567; P:response to defense-related host reactive oxygen species production; IEA:Ensembl
Interpro
InterPro; IPR029393; FUS1
Pfam
Pfam; PF15000; TUSC2;
SMART
PROSITE
PRINTS