LipidDB ID

LipidDB-9606-01301

Entry Name

UniProt Accession

Q92692; A8K5L5; O75455; Q6IBI6; Q96J29;

Theoretical PI

4.74

Molecular Weight

57742.03

Genbank Protein ID

CAA56342.1; AAC23797.1; BAF84019.1; CAG33099.1; EAW57298.1; AAH03091.1; AAC82348.1; AAC82348.1; AAC82348.1; AAC82348.1; AAC82348.1; AAC82348.1; AAD02503.1;

Genbank Nucleotide ID

X80038; AF058448; AK291330; CR456818; CH471126; BC003091; AF044968; AF044962; AF044963; AF044964; AF044966; AF044967; AF050154;

Protein Name

Nectin-2

Protein Synonyms/Alias

Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Poliovirus receptor-related protein 2; CD112;

Gene Name

PVRL2

Gene Synonyms/Alias

HVEB; PRR2;

Created Date

11-JAN-2001

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Probable cell adhesion protein.

Sequence Annotation

Topological domain: 32 360 Extracellular.
Transmembrane: 361 381 Helical.
Topological domain: 382 538 Cytoplasmic.
Domain: 32 156 Ig-like V-type.
Domain: 162 256 Ig-like C2-type 1.
Domain: 261 345 Ig-like C2-type 2.
Modified residue: 433 433 Phosphoserine.

Protein Length

538 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009986; C:cell surface; IDA:BHF-UCL
GO:0005911; C:cell-cell junction; IDA:BHF-UCL
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0016021; C:integral component of membrane; IDA:BHF-UCL
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005915; C:zonula adherens; ISS:BHF-UCL
GO:0050839; F:cell adhesion molecule binding; IPI:BHF-UCL
GO:0015026; F:coreceptor activity; TAS:ProtInc
GO:0042802; F:identical protein binding; IPI:IntAct
GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL
GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW
GO:0001675; P:acrosome assembly; IEA:Ensembl
GO:0034332; P:adherens junction organization; TAS:Reactome
GO:0044406; P:adhesion of symbiont to host; IDA:BHF-UCL
GO:0034329; P:cell junction assembly; TAS:Reactome
GO:0032990; P:cell part morphogenesis; IEA:Ensembl
GO:0045216; P:cell-cell junction organization; TAS:Reactome
GO:0044782; P:cilium organization; IEA:Ensembl
GO:0046814; P:coreceptor-mediated virion attachment to host cell; IDA:BHF-UCL
GO:0007010; P:cytoskeleton organization; IEA:Ensembl
GO:0051654; P:establishment of mitochondrion localization; IEA:Ensembl
GO:0009566; P:fertilization; IEA:Ensembl
GO:0019064; P:fusion of virus membrane with host plasma membrane; IDA:BHF-UCL
GO:0007156; P:homophilic cell adhesion; IDA:BHF-UCL
GO:0002891; P:positive regulation of immunoglobulin mediated immune response; IMP:BHF-UCL
GO:0033005; P:positive regulation of mast cell activation; IMP:BHF-UCL
GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IMP:BHF-UCL
GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IMP:BHF-UCL
GO:0050776; P:regulation of immune response; TAS:Reactome
GO:0007165; P:signal transduction; TAS:GOC
GO:0030382; P:sperm mitochondrion organization; IEA:Ensembl
GO:0007286; P:spermatid development; ISS:BHF-UCL
GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl
GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IMP:BHF-UCL
GO:0060370; P:susceptibility to T cell mediated cytotoxicity; IDA:BHF-UCL

Interpro

InterPro; IPR013162; CD80_C2-set
InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003599; Ig_sub
InterPro; IPR013106; Ig_V-set

Pfam

Pfam; PF08205; C2-set_2;
Pfam; PF07686; V-set;

SMART

SMART; SM00409; IG;

PROSITE

PROSITE; PS50835; IG_LIKE;

PRINTS